Document Detail

Biochemical studies on peptide alkaloids: induction of ion selective mitochondrial swelling.
MedLine Citation:
PMID:  923705     Owner:  NLM     Status:  MEDLINE    
The effect of frangulanine, a cyclopeptide alkaloid isolated from Hovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 muM. The alkaloid showed ion selectivity on the induction of mitochondrial swelling. Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution.
K Kawai; Y Nozawa; Y Ogihara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  33     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1454     Citation Subset:  IM    
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MeSH Terms
Alkaloids / pharmacology*
Cations, Monovalent
Mitochondria, Liver / drug effects*
Peptides, Cyclic / pharmacology*
Reg. No./Substance:
0/Alkaloids; 0/Cations, Monovalent; 0/Ionophores; 0/Peptides, Cyclic

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