Document Detail


Biochemical profile of stone-forming patients with diabetes mellitus.
MedLine Citation:
PMID:  12639639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To test the hypothesis that stone-forming patients with type II diabetes (DM-II) have a high prevalence of uric acid (UA) stones and present with some of the biochemical features of gouty diathesis (GD). METHODS: The demographic and initial biochemical data from 59 stone-forming patients with DM-II (serum glucose greater than 126 mg/dL, no insulin therapy, older than 35 years of age) from Dallas, Texas and Durham, North Carolina were retrieved and compared with data from 58 patients with GD and 116 with hyperuricosuric calcium oxalate urolithiasis (HUCU) without DM. RESULTS: UA stones were detected in 33.9% of patients with DM-II compared with 6.2% of stone-forming patients without DM (P <0.001). Despite similar ingestion of alkali, the urinary pH in patients with DM-II and UA stones (n = 20) was low (pH = 5.5), as it is in patients with GD, and was significantly lower than in patients with HUCU. The urinary pH in patients with DM-II and calcium stones (n = 39) was intermediate between that in those with DM-II and UA stones and those with HUCU. However, both DM groups had fractional excretion of urate that was not depressed, as it is in those with GD, and was comparable to the value obtained in those with HUCU. The urinary content of undissociated UA was significantly higher, and the saturation of calcium phosphate (brushite) and sodium urate was significantly lower in those with DM-II and UA stones than in those with HUCU. CONCLUSIONS: Stone-forming patients with DM-II have a high prevalence of UA stones. Diabetic patients with UA stones share a key feature of those with GD, namely the passage of unusually acid urine, but not the low fractional excretion of urate.
Authors:
Charles Y C Pak; Khashayar Sakhaee; Orson Moe; Glenn M Preminger; John R Poindexter; Roy D Peterson; Paul Pietrow; Wesley Ekeruo
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Urology     Volume:  61     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-7     Citation Subset:  IM; S    
Affiliation:
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75390-8885, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Blood Glucose / analysis
Calcium Oxalate / urine
Comorbidity
Diabetes Mellitus, Type 2 / epidemiology,  metabolism*,  urine
Disease Susceptibility
Female
Gout / epidemiology,  etiology
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Prevalence
Uric Acid / urine
Urinary Calculi / epidemiology,  metabolism*,  urine
Urine / chemistry
Grant Support
ID/Acronym/Agency:
M01-RR00633/RR/NCRR NIH HHS; P01-DK20543/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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