Document Detail

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients.
MedLine Citation:
PMID:  469639     Owner:  NLM     Status:  MEDLINE    
Blood serum of heavily burned patients contains neurotoxic substances which are not present in normal control sera. In the present paper, we describe the purification by gel filtration and ultracentrifugation of such a neurotoxic factor. The purified factor appeared to be a high molecular weight (2 to 3.10(6) daltons) lipoprotein. This factor was present in all the sera of patients with more than 35 per cent of the body surface burned. When injected into rabbits the lipoprotein caused a flattening of the EEG tracing, then trembling and convulsions with bursts of spikes on the EEG. The activity of this neurotoxic substance was enhanced when the permeability of the blood-brain barrier was increased by previous intraventricular injection of collagenase. The presence of such a neurotoxic factor in the blood serum of burned patients, together with the increased serum collagenase activity they exhibit may explain the neurotoxic symptoms observed in them.
C Sepulchre; F Moati; M Miskulin; O Huisman; E Moczar; A M Robert; R Monteil; J Guilbaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  127     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / isolation & purification*
Burns / etiology*
Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Neurotoxins / blood,  isolation & purification*,  pharmacology
Reg. No./Substance:
0/Blood Proteins; 0/Neurotoxins

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