Document Detail

Biochemical and pharmacologic comparison of thrombolytic agents.
MedLine Citation:
PMID:  8888099     Owner:  NLM     Status:  MEDLINE    
The number of thrombolytic drugs for the management of acute myocardial infarction is rapidly expanding. New agents, some of which are biochemically modified versions of currently available thrombolytics, will soon arrive in the marketplace. The pharmacologic differences of the new drugs are the basis for clinical differences such as enhanced clot lysis and prolonged elimination half-life. Ultimately, these features may result in improved infarct artery patency and patient survival.
K A Stringer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  16     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1997-01-31     Completed Date:  1997-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119S-126S     Citation Subset:  IM    
Department of Pharmacy Practice, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA.
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MeSH Terms
Amino Acid Sequence
Anistreplase / chemistry,  therapeutic use
Fibrinolytic Agents / therapeutic use*
Molecular Sequence Data
Myocardial Infarction / drug therapy*
Plasminogen Activators / chemistry,  therapeutic use
Recombinant Proteins / chemistry,  therapeutic use
Streptokinase / chemistry,  therapeutic use
Tissue Plasminogen Activator*
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Recombinant Proteins; 133652-38-7/reteplase; 81669-57-0/Anistreplase; EC 3.4.-/Streptokinase; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator
Comment In:
Pharmacotherapy. 1997 Jul-Aug;17(4):850-2   [PMID:  9250573 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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