| Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. | |
| | |
MedLine Citation:
|
PMID: 21240854 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Clinicopathological studies on the effects of combining immunostimulant drugs (levamisole) with anti-cancer drugs (chlorambucil) revealed the enhancement of the latter against Ehrlich ascites carcinoma-bearing mice and resulted in a reduction in the size of tumour. An evaluation of liver and kidney functions showed a significant increase of alanine transaminase (ALT), aspartate transaminase (AST) and creatinine in all groups. Histopathological studies of one group that received an intraperitoneal injection of Ehrlich ascites carcinoma cells (2.5 × 106) showed that hepatic parenchyma revealed degenerative changes. The portal area was oedematous and showed rounded cell aggregations. Cell death within hypertrophied Kupper cells was observed in some hepatic cells. The neoplastic emboli could be seen either inside blood vessels or hepatic sinusoids, while another group which had been treated orally with a combination of Leukeran(™) (0.2 mg/kg body weight) and levamisole (5 mg/kg body weight) revealed that hepatic parenchyma revealed massive necrosis with proliferative bile duct epithelium. No neoplastic cells were observed without the hepatic parenchyma, while the renal cortex presented a large number of lymphocytes and plasma cells forming bands or aggregates, mainly around the blood vessels. It was concluded that the addition of levamisole to chlorambucil improved the anti-cancer effect of chlorambucil against Ehrlich ascites carcinoma. However, it had adverse effects on the liver and kidneys as shown by liver and kidney function tests and confirmed by histopathology. |
| | |
Authors:
|
Fakhry S Salem; Mohamed O T Badr; Ahmed N F Neamat-Allah |
Related Documents
:
|
11112704 - Cdc28-clb mitotic kinase negatively regulates bud site assembly in the budding yeast. 16663044 - H fluxes in excised samanea motor tissue : ii. rhythmic properties. 20037474 - Apc-targeted raa1 degradation mediates the cell cycle and root development in plants. 21471934 - Selective cytotoxicity of goniothalamin against hepatoblastoma hepg2 cells. 17928064 - The linkage of neural progenitor cell cycle profiles between embryonic and adult stroke... 16682814 - Myogenic differentiation of p53- and rb-deficient immortalized and transformed bovine f... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Veterinaria italiana Volume: 47 ISSN: 1828-1427 ISO Abbreviation: Vet. Ital. Publication Date: 2011 Jan-Mar |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0201543 Medline TA: Vet Ital Country: Italy |
Other Details:
|
Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, 1 Alzeraa Street, Postal Code 44511, Zagazig City, Sharkia Province, Egypt. drnemovete@yahoo.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiostrongylus vasorum in 20 dogs in the province of Chieti, Italy.
Next Document: The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anaes...