| Biochemical and morphological changes in the digestive tract of rats after prenatal and postnatal malnutrition. | |
| | |
MedLine Citation:
|
PMID: 2502904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Six-week-old rats subjected to prenatal and postnatal dietary restriction (maternal and weanling intake = 50% that of controls) were studied. Compared with controls, malnourished rats not only had reduced body (78 +/- 12 vs 187 +/- 21 g) and organ weights (small intestine: 4.51 +/- 0.46 vs 9.89 +/- 0.61 g; colon: 0.75 +/- 0.08 vs 1.77 +/- 0.18 g; liver: 2.75 +/- 0.34 vs 9.13 +/- 1.33 g; pancreas: 0.78 +/- 0.14 vs 1.67 +/- 0.49 g) but also decreased body weight-length ratios (6.5 +/- 0.3 vs 10.8 +/- 1.4 g/cm) and serum albumin levels. The small intestinal mucosa was hypotrophic (protein-DNA ratio: 5.02 +/- 1.43 vs 8.82 +/- 0.68, malnourished vs controls, respectively) with reduced mucosal thickness, villus height, and crypt depth. Specific activities of lactase, maltase, and sucrase were diminished (53%, 66%, 54% of control values, respectively). Colonic mucosa was hypoplastic with decreased mucosal thickness and crypt depth. Liver and pancreas were both hypotrophic and hypoplastic. The findings suggest that, in contrast to colonic mucosa, pancreas, and liver, the small intestinal mucosa maintained cell number during prolonged prenatal and postnatal malnutrition. |
| | |
Authors:
|
A Firmansyah; L Suwandito; D Penn; E Lebenthal |
Related Documents
:
|
11175494 - Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect... 7104464 - Salicylamide pharmacokinetics in healthy males: dietary effect. 2346674 - Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of cer... 12221234 - A high retinol dietary intake increases its apical absorption by the proximal small int... 11560124 - Effects of nitric oxide synthase inhibition and low-salt diet on blood pressure and mes... 7547834 - Effect of dietary protein quality on energy metabolism in growing chickens. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 50 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1989 Aug |
Date Detail:
|
Created Date: 1989-09-07 Completed Date: 1989-09-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 261-8 Citation Subset: AIM; IM |
Affiliation:
|
International Institute for Infant Nutrition and Gastrointestinal Disease, Children's Hospital of Buffalo, NY 14222. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn / growth & development* Colon / metabolism, pathology DNA / analysis Digestive System / metabolism*, pathology Female Intestinal Mucosa / enzymology Intestine, Small / metabolism, pathology Liver / metabolism, pathology Nutrition Disorders / metabolism*, pathology Organ Size Pancreas / metabolism, pathology Pregnancy Prenatal Exposure Delayed Effects* Proteins / analysis Rats Rats, Inbred Strains Sucrase / metabolism alpha-Glucosidases / metabolism beta-Galactosidase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; 9007-49-2/DNA; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.48/Sucrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early image acquisition after administration of indium-111 platelets in clinically suspected deep ve...
Next Document: Fast neutron radiotherapy in the treatment of locally advanced adenocarcinoma of the prostate. Clini...