Document Detail

Biochemical and molecular aspects of vascular adrenergic regulation of blood pressure in the elderly.
MedLine Citation:
PMID:  21961055     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Hypertension, orthostatic hypotension, arterial insufficiency, and atherosclerosis are common disorders in the elderly that lead to significant morbidity and mortality. One common factor to these conditions is an age-related decline in vascular beta-adrenergic receptor-mediated function and subsequent cAMP generation. Presently, there is no single cellular factor that can explain this age-related decline, and thus, the primary cause of this homeostatic imbalance is yet to be identified. However, the etiology is clearly associated with an age-related change in the ability of beta-adrenergic receptor to respond to agonist at the cellular level in the vasculature. This paper will review what is presently understood regarding the molecular and biochemical basis of age-impaired beta-adrenergic receptor-mediated signaling. A fundamental understanding of why β-AR-mediated vasorelaxation is impaired with age will provide new insights and innovative strategies for the management of multiple clinical disorders.
William E Schutzer; Scott L Mader
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Publication Detail:
Type:  Journal Article     Date:  2011-09-22
Journal Detail:
Title:  International journal of hypertension     Volume:  2012     ISSN:  2090-0392     ISO Abbreviation:  Int J Hypertens     Publication Date:  2012  
Date Detail:
Created Date:  2011-09-30     Completed Date:  2011-11-10     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  101538881     Medline TA:  Int J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  915057     Citation Subset:  -    
Portland VA Medical Center and Research Service-RD 26, Oregon Health and Science University School of Medicine, P.O. Box 1034, Portland, OR 97201, USA.
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