| Biochemical mechanisms of resistance to insecticides. | |
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MedLine Citation:
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PMID: 6559114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The principal biochemical mechanisms of resistance to insecticides involve either modified, less sensitive cholinesterase, esterase action, glutathione S-transferase action or cytochrome P-450-dependent monooxygenation. Both quantitative and qualitative differences in cytochrome P-450 isozymes are under genetic control and both are related to resistance. Recent characterization studies involving ligand binding and multiplicity of isozymes in Musca domestica (the housefly) are discussed in relation to resistance. The recent demonstration that multiple isozymes of glutathione S-transferase exist in susceptible and resistant insects is of interest, and some re-examination of their role in the mechanism of resistance is required. Esterases are a heterogeneous group of enzymes whose role in resistance has often been suggested but seldom rigorously defined. Purification studies in the green rice leafhopper, Nephotettix cincticeps, have involved an enzyme with carboxylesterase, phosphotriesterase and pyrethroid esterase activities. A similar enzyme, but without pyrethroid esterase activity, is also found in the housefly. In resistance such enzymes may serve either to catalyse hydrolysis or as binding proteins. It has been suggested, from time to time, that regulator genes, enzyme induction and gene magnification all play a part in controlling biochemical mechanisms of resistance, although clearly defined evidence has not always been brought forward. These hypotheses are re-examined. |
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Authors:
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E Hodgson; N Motoyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ciba Foundation symposium Volume: 102 ISSN: 0300-5208 ISO Abbreviation: Ciba Found. Symp. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-03-16 Completed Date: 1984-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356636 Medline TA: Ciba Found Symp Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 167-89 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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metabolism Animals Cytochrome P-450 Enzyme System / metabolism Esterases / metabolism Glutathione / metabolism Insecticide Resistance* |
| Chemical | |
Reg. No./Substance:
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70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System; EC 3.1.-/Esterases; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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