| Biochemical markers for the prediction of spontaneous pre-term birth. | |
MedLine Citation:
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PMID: 12427396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to identify predictive biochemical markers for preterm labor. METHODS: In this prospective study we included 225 asymptomatic Caucasian women consecutively enrolled at 24 weeks of gestation. The following data were collected only once at 24 weeks of gestation: vaginal pH, vaginal fFN, cervical and serum concentration of IL-6, IL-8 and TNFalpha, maternal blood serum, ferritin. Student's t-test, the chi(2)-test and multiple linear regression were used as statistical methods. RESULTS: There were no differences between the age of patients, parity and gestational age at sampling between women who delivered at term and those who delivered pre-term (<37 weeks' gestation). There was a significant increase of cervical IL-6 (pre-term 608+/-1595 pg/l vs. at term 58.9+/-112 pg/l) and serum ferritin (pre-term microg/l 74.4+/-1.1 vs. at term 26.3+/-56.5 microg/l) in pregnant women who delivered pre-term (P<0.05). No differences in cervical IL-8 and cervical TNFalpha between pre-term and term deliveries were found. Multiple linear regression confirmed that the vaginal pH value and cervical fFN test were the best predictive biochemical markers of pre-term birth (standardized coefficient Beta=0.33 and 0.22, respectively). CONCLUSIONS: In order to evaluate pregnancies for pre-term labor, the presence of pH>4.5 and a positive fFN test seems to be predictive of subsequent pre-term delivery. |
Authors:
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D M Paternoster; A Stella; P Gerace; F Manganelli; M Plebani; D Snijders; U Nicolini |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 79 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-12 Completed Date: 2003-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 123-9 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Pathophysiology of Human Reproduction, Padova, Italy. paternod@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis Case-Control Studies Female Ferritins / blood* Fetus / chemistry* Fibronectins / analysis* Humans Hydrogen-Ion Concentration Interleukin-6 / analysis* Linear Models Obstetric Labor, Premature / diagnosis* Odds Ratio Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Prospective Studies Risk Factors Vagina / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibronectins; 0/Interleukin-6; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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