Document Detail

Biochemical markers for the prediction of spontaneous pre-term birth.
MedLine Citation:
PMID:  12427396     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to identify predictive biochemical markers for preterm labor. METHODS: In this prospective study we included 225 asymptomatic Caucasian women consecutively enrolled at 24 weeks of gestation. The following data were collected only once at 24 weeks of gestation: vaginal pH, vaginal fFN, cervical and serum concentration of IL-6, IL-8 and TNFalpha, maternal blood serum, ferritin. Student's t-test, the chi(2)-test and multiple linear regression were used as statistical methods. RESULTS: There were no differences between the age of patients, parity and gestational age at sampling between women who delivered at term and those who delivered pre-term (<37 weeks' gestation). There was a significant increase of cervical IL-6 (pre-term 608+/-1595 pg/l vs. at term 58.9+/-112 pg/l) and serum ferritin (pre-term microg/l 74.4+/-1.1 vs. at term 26.3+/-56.5 microg/l) in pregnant women who delivered pre-term (P<0.05). No differences in cervical IL-8 and cervical TNFalpha between pre-term and term deliveries were found. Multiple linear regression confirmed that the vaginal pH value and cervical fFN test were the best predictive biochemical markers of pre-term birth (standardized coefficient Beta=0.33 and 0.22, respectively). CONCLUSIONS: In order to evaluate pregnancies for pre-term labor, the presence of pH>4.5 and a positive fFN test seems to be predictive of subsequent pre-term delivery.
D M Paternoster; A Stella; P Gerace; F Manganelli; M Plebani; D Snijders; U Nicolini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  79     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-12     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Department of Gynecology and Pathophysiology of Human Reproduction, Padova, Italy.
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MeSH Terms
Biological Markers / analysis
Case-Control Studies
Ferritins / blood*
Fetus / chemistry*
Fibronectins / analysis*
Hydrogen-Ion Concentration
Interleukin-6 / analysis*
Linear Models
Obstetric Labor, Premature / diagnosis*
Odds Ratio
Predictive Value of Tests
Pregnancy Trimester, Second
Prospective Studies
Risk Factors
Vagina / chemistry*
Reg. No./Substance:
0/Biological Markers; 0/Fibronectins; 0/Interleukin-6; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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