| Biochemical markers of possible immunodepression in military training in harsh environments. | |
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MedLine Citation:
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PMID: 20358704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolonged, exhaustive exercise frequently leads to an increased incidence of upper respiratory tract illness (URTI) which is linked to transient immunodepression. We investigated potential biochemical markers of stress and fatigue, and URTI symptoms as a surrogate of immunodepression, in US Marines undergoing intensive winter training at altitude. Selected plasma amino acids and leptin (p[Lep]) were measured as possible markers of fatigue and immunodepression, together with nonesterified fatty acids (p[NEFA]) and total antioxidant capacity (p[TAC]). Changes were observed in plasma free tryptophan (p[FT]), p[Gln], p[Lep], p[NEFA], p[TAC] but not branched chain amino acids (p[BCAA]). p[FT] decreased markedly. Resting p[Gln] decreased overall after one month at altitude. p[Gln] routinely decreases 1-2 hrs after prolonged exercise. Importantly, we observed early morning decreases in p[Gln], suggesting a cumulative effect of prolonged activity, stress, and fatigue. Concomitantly, individuals with highest illness scores had the greatest p[Gln] decrease: low p[Gln] may therefore be associated with a diminished stress tolerance. |
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Authors:
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Linda M Castell; C Douglas Thake; Wayne Ensign |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Military medicine Volume: 175 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: United States |
Other Details:
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Languages: eng Pagination: 158-65 Citation Subset: IM |
Affiliation:
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University of Oxford, Green Templeton College, Woodstock Road, Oxford OX2 6HG, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism Biological Markers / blood* Chromatography, High Pressure Liquid Environmental Exposure / adverse effects* Enzyme-Linked Immunosorbent Assay Exercise Tolerance / immunology* Fatty Acids, Nonesterified / blood Glutamine / blood Humans Immune System / immunology* Immune Tolerance / physiology* Leptin / blood Male Military Personnel* Respiratory Tract Diseases / blood*, etiology, immunology Retrospective Studies Tryptophan / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Fatty Acids, Nonesterified; 0/Leptin; 56-85-9/Glutamine; 73-22-3/Tryptophan |
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