Document Detail


Biochemical markers of possible immunodepression in military training in harsh environments.
MedLine Citation:
PMID:  20358704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolonged, exhaustive exercise frequently leads to an increased incidence of upper respiratory tract illness (URTI) which is linked to transient immunodepression. We investigated potential biochemical markers of stress and fatigue, and URTI symptoms as a surrogate of immunodepression, in US Marines undergoing intensive winter training at altitude. Selected plasma amino acids and leptin (p[Lep]) were measured as possible markers of fatigue and immunodepression, together with nonesterified fatty acids (p[NEFA]) and total antioxidant capacity (p[TAC]). Changes were observed in plasma free tryptophan (p[FT]), p[Gln], p[Lep], p[NEFA], p[TAC] but not branched chain amino acids (p[BCAA]). p[FT] decreased markedly. Resting p[Gln] decreased overall after one month at altitude. p[Gln] routinely decreases 1-2 hrs after prolonged exercise. Importantly, we observed early morning decreases in p[Gln], suggesting a cumulative effect of prolonged activity, stress, and fatigue. Concomitantly, individuals with highest illness scores had the greatest p[Gln] decrease: low p[Gln] may therefore be associated with a diminished stress tolerance.
Authors:
Linda M Castell; C Douglas Thake; Wayne Ensign
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Military medicine     Volume:  175     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-65     Citation Subset:  IM    
Affiliation:
University of Oxford, Green Templeton College, Woodstock Road, Oxford OX2 6HG, UK.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism
Biological Markers / blood*
Chromatography, High Pressure Liquid
Environmental Exposure / adverse effects*
Enzyme-Linked Immunosorbent Assay
Exercise Tolerance / immunology*
Fatty Acids, Nonesterified / blood
Glutamine / blood
Humans
Immune System / immunology*
Immune Tolerance / physiology*
Leptin / blood
Male
Military Personnel*
Respiratory Tract Diseases / blood*,  etiology,  immunology
Retrospective Studies
Tryptophan / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Fatty Acids, Nonesterified; 0/Leptin; 56-85-9/Glutamine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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