Document Detail

Biochemical markers of perinatal brain damage.
MedLine Citation:
PMID:  20036928     Owner:  NLM     Status:  MEDLINE    
Hypoxia-ischemia constitutes a risk in infants by altering cerebral blood flow regulatory mechanisms and causing loss of cerebral vascular auto-regulation. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation leading to cell death and tissue damage. These dramatic phenomena represent a common repertoire in infants complicated by perinatal acute or chronic hypoxia. To date, despite accurate perinatal and intra-operative monitoring, the post-insult period is crucial, since clinical symptoms and monitoring parameters may be of no avail and therapeutic window for pharmacological intervention (6-12 hours) may be limited, at a time when brain damage is already occurring. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk infants. The present review is aimed at investigating the role as circulating biochemical markers such as adrenomedullin, S100B, activin A, neuronal specific enolase (NSE), glial fibrillary acid protein (GFAP), in the cascade of events leading to ischemia reperfusion injury in infants complicated by perinatal asphyxia.
Pasquale Florio; Raul Abella; Emanuela Marinoni; Romolo Di Iorio; Giovanni Li Volti; Fabio Galvano; Giacomo Pongiglione; Alessandro Frigiola; Serena Pinzauti; Felice Petraglia; Diego Gazzolo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  2     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-72     Citation Subset:  IM    
Department of Pediatrics, University of Siena, Siena, Italy.
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MeSH Terms
Asphyxia Neonatorum / complications*,  epidemiology
Biological Markers / metabolism*
Brain / metabolism*
Carrier Proteins
Hypoxia, Brain / diagnosis*,  etiology,  physiopathology*
Infant, Newborn
Milk, Human / chemistry
Nerve Growth Factors
Oxygen / metabolism
Reperfusion Injury / diagnosis,  metabolism*
S100 Proteins
Spectroscopy, Near-Infrared / methods
Reg. No./Substance:
0/Biological Markers; 0/Carrier Proteins; 0/NSE1 protein, human; 0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 0/activin A; 104625-48-1/Activins; 148498-78-6/Adrenomedullin; 7782-44-7/Oxygen

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