Document Detail


Biochemical markers of myocardial injury in the pericardial fluid of patients undergoing heart surgery.
MedLine Citation:
PMID:  18258649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to compare cardiac markers in the pericardial fluid and serum in order to evaluate preoperative myocardial injury. Thirty patients were divided into three groups. The first group (AVR; n=10) received an aortic valve replacement. The second group (SA; n=10) included patients with stable angina who underwent elective coronary artery bypass grafting (CABG). The third group (ACS; n=10) included patients with acute coronary syndrome who underwent urgent CABG. Pericardial fluid and venous samples were taken after opening the pericardium and 24 h postoperatively. Serum and pericardial concentration of troponin I (cTnI), creatine kinase (CK), its MB isoenzyme (CK-MB) and myoglobin were determined. Preoperative pericardial cTnI was significantly (P<0.01) higher than in serum in all groups. Preoperative pericardial CK, CK-MB and myoglobin were significantly (P<0.01) lower than in serum in groups AVR and SA. Preoperative pericardial and serum cTnI were significantly higher in the ACS than in AVR and SA groups (P<0.01). Postoperative pericardial concentration of all markers was significantly higher (P<0.01) than in serum in all groups. We conclude that preoperative pericardial accumulation of cTnI may reflect subclinical injury which may not be demonstrated by the usual laboratory tests.
Authors:
Angel L Fernández; José B García-Bengochea; Julián Alvarez; José R González Juanatey
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-02-07
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  7     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  373-6; discussion 376-7     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, University Hospital of Santiago, 15706 Santiago de Compostela, Spain. alfg@secardiologia.es
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / etiology,  surgery
Aged
Aged, 80 and over
Angina Pectoris / etiology,  surgery
Aortic Valve / surgery*
Biological Markers / blood,  metabolism*
Coronary Artery Bypass*
Creatine Kinase / metabolism
Creatine Kinase, MB Form / metabolism
Emergency Treatment
Extracellular Fluid / enzymology,  metabolism*
Female
Heart Valve Prosthesis Implantation*
Humans
Male
Middle Aged
Myocardial Ischemia / complications,  metabolism,  pathology,  surgery*
Myocardium / enzymology,  metabolism*,  pathology
Myoglobin / metabolism
Pericardium / enzymology,  metabolism*
Prospective Studies
Surgical Procedures, Elective
Time Factors
Treatment Outcome
Troponin I / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Myoglobin; 0/Troponin I; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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