|Biochemical markers of myocardial injury in the pericardial fluid of patients undergoing heart surgery.|
|PMID: 18258649 Owner: NLM Status: MEDLINE|
|The purpose of this study was to compare cardiac markers in the pericardial fluid and serum in order to evaluate preoperative myocardial injury. Thirty patients were divided into three groups. The first group (AVR; n=10) received an aortic valve replacement. The second group (SA; n=10) included patients with stable angina who underwent elective coronary artery bypass grafting (CABG). The third group (ACS; n=10) included patients with acute coronary syndrome who underwent urgent CABG. Pericardial fluid and venous samples were taken after opening the pericardium and 24 h postoperatively. Serum and pericardial concentration of troponin I (cTnI), creatine kinase (CK), its MB isoenzyme (CK-MB) and myoglobin were determined. Preoperative pericardial cTnI was significantly (P<0.01) higher than in serum in all groups. Preoperative pericardial CK, CK-MB and myoglobin were significantly (P<0.01) lower than in serum in groups AVR and SA. Preoperative pericardial and serum cTnI were significantly higher in the ACS than in AVR and SA groups (P<0.01). Postoperative pericardial concentration of all markers was significantly higher (P<0.01) than in serum in all groups. We conclude that preoperative pericardial accumulation of cTnI may reflect subclinical injury which may not be demonstrated by the usual laboratory tests.|
|Angel L Fernández; José B García-Bengochea; Julián Alvarez; José R González Juanatey|
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|Type: Comparative Study; Journal Article Date: 2008-02-07|
|Title: Interactive cardiovascular and thoracic surgery Volume: 7 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2008 May|
|Created Date: 2008-05-22 Completed Date: 2008-07-03 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England|
|Languages: eng Pagination: 373-6; discussion 376-7 Citation Subset: IM|
|Department of Cardiac Surgery, University Hospital of Santiago, 15706 Santiago de Compostela, Spain. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Acute Coronary Syndrome
Aged, 80 and over
Angina Pectoris / etiology, surgery
Aortic Valve / surgery*
Biological Markers / blood, metabolism*
Coronary Artery Bypass*
Creatine Kinase / metabolism
Creatine Kinase, MB Form / metabolism
Extracellular Fluid / enzymology, metabolism*
Heart Valve Prosthesis Implantation*
Myocardial Ischemia / complications, metabolism, pathology, surgery*
Myocardium / enzymology, metabolism*, pathology
Myoglobin / metabolism
Pericardium / enzymology, metabolism*
Surgical Procedures, Elective
Troponin I / metabolism
|0/Biological Markers; 0/Myoglobin; 0/Troponin I; EC 188.8.131.52/Creatine Kinase; EC 184.108.40.206/Creatine Kinase, MB Form|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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