Document Detail

Biochemical markers in the management of pulmonary hypertension.
MedLine Citation:
PMID:  15729606     Owner:  NLM     Status:  MEDLINE    
Pulmonary arterial hypertension (PAH) is a severe disease usually diagnosed by echocardiography and further confirmed by right heart catheterisation. Follow-up under treatment consists in assessment of clinical signs, various types of exercise testing and repeated echocardiograms. Several molecules which can be measured in the blood or sometimes in other biological fluids are known to be elevated in PAH. The most extensively studied are members of the family of natriuretic peptides, uric acid, and products generated by nitric oxide activity. Due to the low prevalence of PAH and their suboptimal specificity, these potential markers are generally of modest positive predictive value which precludes their use as screening tools. However, some of them correlate significantly with prognosis, and thus, in conjunction with classical clinical and paraclinical parameters, they may be a further aid to clinical decision-making for the specialist dealing with PAH patients.
John-David Aubert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Swiss medical weekly     Volume:  135     ISSN:  1424-7860     ISO Abbreviation:  Swiss Med Wkly     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-05-17     Revised Date:  2011-02-15    
Medline Journal Info:
Nlm Unique ID:  100970884     Medline TA:  Swiss Med Wkly     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Service de Pneumologie, CHUV, Lausanne, Switzerland.
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MeSH Terms
Biological Markers
Hypertension, Pulmonary* / blood,  diagnosis,  metabolism
Natriuretic Peptides* / biosynthesis,  blood,  physiology
Nitric Oxide / metabolism
Troponin T / metabolism
Uric Acid / blood
Reg. No./Substance:
0/Biological Markers; 0/Natriuretic Peptides; 0/Troponin T; 10102-43-9/Nitric Oxide; 69-93-2/Uric Acid

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