Document Detail


Biochemical markers of endothelial activation in primary hyperparathyroidism.
MedLine Citation:
PMID:  16523414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with primary hyperparathyroidism (PHPT) have impaired vasodilation both dependent and independent of endothelium. The aims of our study were to measure three different biochemical markers of endothelial activation, i. e., plasma thrombomodulin, soluble(s) E-selectin, and von Willebrand factor, in PHPT patients before and one year after successful parathyroidectomy, and to distinguish the potential effect of hypercalcemia and/or high parathyroid hormone from that of major cardiovascular risk factors (diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking habit) on endothelial function. Twenty consecutive patients with PHPT subdivided into two groups according to the absence (n = 8) or presence (n = 12) of one or more risk factors, and fifteen healthy normocalcemic subjects were studied. Baseline thrombomodulin levels were similar in the groups with and without risk factors, and in controls. In contrast, sE-selectin and von Willebrand factor were higher in PHPT patients with risk factors than in those without risk factors (p < 0.05 and p < 0.01, respectively) and controls (p < 0.01). Neither thrombomodulin nor sE-selectin changed after parathyroidectomy in either PHPT group. Plasma von Willebrand factor decreased (p < 0.01) in patients without risk factors, while persisting at high levels in patients with risk factors. In conclusion, in spite of a limitation due to the small number of patients, our study suggests that classic cardiovascular risk factors seem to be the main determinants for the high plasma levels of sE-selectin and vWF in PHPT. Together with unaltered thrombomodulin and sE-selectin levels, a plasma vWF decrease after parathyroidectomy might reflect a specific mechanism of its endothelial calcium- and/or PTH-stimulated secretion in some PHPT patients without risk factors. Whether a vWF reduction after parathyroidectomy may be used as a biochemical index for improved endothelial function in PHPT patients without risk factors has yet to be demonstrated in larger studies.
Authors:
F Fallo; G Cella; A Casonato; M Ermani; R Vettor; S Zanella; F Lumachi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  38     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-05-18     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Department of Medical and Surgical Sciences, University of Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism
Cardiovascular Diseases / blood,  etiology,  pathology
E-Selectin / blood
Endothelium, Vascular / pathology,  secretion*
Female
Follow-Up Studies
Humans
Hyperparathyroidism, Primary / blood*,  complications,  pathology,  surgery
Male
Middle Aged
Parathyroidectomy / methods
Risk Factors
Thrombomodulin / blood
Vasodilation
von Willebrand Factor / analysis*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/E-Selectin; 0/Thrombomodulin; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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