| Biochemical markers for brain damage after cardiac surgery -- time profile and correlation with cognitive dysfunction. | |
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MedLine Citation:
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PMID: 12027849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cerebral dysfunction is common after cardiac surgery and may be reflected in increasing blood concentrations of neuron specific enolase (NSE) and S-100 beta protein. The aim of the study was to determine the optimal timing of blood sampling. METHODS: We studied 15 patients undergoing coronary artery bypass grafting. Serum concentrations of NSE and S-100 beta protein were measured before surgery and after 12, 18, 24, 30, and 36 h. Neuropsychological testing was performed before surgery, at discharge from hospital and after 3 months. RESULTS: Serum concentrations of both NSE and S-100 beta protein increased significantly. At the first postoperative test, seven patients had cognitive dysfunction and a significant correlation was found between the composite z-score and the increase in the NSE level after 36 h (R = 0.76, P=0.001). The median increase in NSE after 36 h was 4.1 microg/l in patients having cognitive dysfunction and 0.9 microg/l in the remaining patients (P<0.05). No significant correlation was found between cognitive dysfunction and the increase in S-100 beta protein. After 3 months, no statistically significant correlation was found between either NSE or S-100 beta protein and cognitive dysfunction. CONCLUSION: NSE seems to be a useful blood marker for early cognitive dysfunction after coronary artery bypass grafting, optimal timing of blood sampling being at approximately 36 h postoperatively. |
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Authors:
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L S Rasmussen; M Christiansen; K Eliasen; K Sander-Jensen; J T Moller |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 46 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-24 Completed Date: 2002-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 547-51 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Isr@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthesia Biological Markers Cardiac Surgical Procedures / adverse effects* Cardiopulmonary Bypass / adverse effects Cognition Disorders / etiology*, metabolism*, psychology Female Humans Male Middle Aged Neuropsychological Tests Phosphopyruvate Hydratase / blood Postoperative Complications / metabolism*, psychology* S100 Proteins / blood Verbal Learning / physiology Wechsler Scales |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/S100 Proteins; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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