Document Detail

Biochemical markers of bone turnover in osteoporosis.
MedLine Citation:
PMID:  19078189     Owner:  NLM     Status:  In-Data-Review    
Postmenopausal osteoporosis is characterized by an increased frequency of activation of bone remodeling units and by a relative increase in bone resorption. Biochemical markers for bone turnover are simple noninvasive tools for evaluating these changes. Some are enzymes produced by osteoblasts or osteoclasts, whereas others are components of the bone matrix that are released in the bloodstream during bone formation or resorption. The most effective in osteoporosis are serum bone alkaline phosphatase and osteocalcin for bone formation, and urinary pyridinoline and deoxypyridinoline for bone resorption. In addition to being sensitive, these markers have shown evidence in recent experimental studies of contributing usefully to the evaluation of the osteoporosis or fracture risk and to the monitoring of treatments for osteoporosis.
P D Delmas; J Beaudreuil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  3     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  2008-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  -    
Unité INSERN1 403, Hôpital E. Herriot, Lyon, France (P.D.D.) and Centre Viggo-Petersen, Hôpital Lariboisière, Paris, France (J.B.).
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