Document Detail


Biochemical markers of alcoholism.
MedLine Citation:
PMID:  17579567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol and alcohol-related diseases have become a major cause of death in Western countries. The most sensitive and specific of the commonly used biomarkers of alcohol intake are carbohydrate-deficient transferrin (CDT), and the combination of gamma-glutamyltransferase (GGT) and CDT. Other widely used laboratory markers are GGT, mean corpuscular volume of erythrocytes and the ratio of aspartate aminotransferase to alanine aminotransferase. Blood ethanol levels reveal recent alcohol use. However, more specific and sensitive biomarkers to improve the detection of excessive alcohol use at an early stage are needed. New biomarkers, not yet used in routine clinical work, include phosphatidylethanol, fatty acid ethyl esters, ethyl glucuronide, sialic acid, and acetaldehyde adducts.
Authors:
Minna L Hannuksela; Marja K Liisanantti; Antti E T Nissinen; Markku J Savolainen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  45     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-17     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  953-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland. minna.hannuksela@oulu.fi
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Alcoholism / diagnosis*
Biological Markers / analysis*
Humans
Mass Screening / methods
Chemical
Reg. No./Substance:
0/Biological Markers

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