| Biochemical and immunohistochemical analysis of orotic acid-induced fatty liver. | |
| | |
MedLine Citation:
|
PMID: 1811353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Orotic acid-induced fatty livers were examined by biochemical and immunohistochemical approaches. Lipid peroxide levels by the thiobarbituric acid method and glutathione-peroxidase (GSH-PO) activity in the liver homogenates from orotic administered rats were similar to those of controls. Immunohistochemical localization of GSH-PO in orotic acid-induced fatty liver was mainly observed in the portal zone of the hepatic lobules. This staining pattern of GSH-PO was similar to that of the controls. No remarkable changes in GSH-PO staining patterns were detected in orotic acid-induced fatty liver. Our data strongly suggested that no lipid peroxidation is actively involved in the genesis of fatty liver due to the administration of orotic acid, and GSH-PO a protective enzyme against lipid peroxidation, was not inhibited by orotic acid-induced fatty liver. |
| | |
Authors:
|
M Murakoshi; H Suemizu; S Takekoshi; M Misawa; K Watanabe |
Related Documents
:
|
12014573 - Relevance of apolipoproteins in the development of fatty liver and fatty liver-related ... 18029843 - Interobserver and intraobserver variability in the sonographic assessment of fatty liver. 6831033 - Cholesterol and mevalonic acid are independent requirements for the in vitro proliferat... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Tokai journal of experimental and clinical medicine Volume: 16 ISSN: 0385-0005 ISO Abbreviation: Tokai J. Exp. Clin. Med. Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-05-29 Completed Date: 1992-05-29 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7704186 Medline TA: Tokai J Exp Clin Med Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 197-201 Citation Subset: IM |
Affiliation:
|
Department of Pathology, School of Medicine, Tokai University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Fatty Liver / chemically induced*, metabolism, pathology Glutathione Peroxidase / metabolism Immunohistochemistry Lipid Peroxidation / drug effects Lipid Peroxides / metabolism Male Orotic Acid / toxicity* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Peroxides; 65-86-1/Orotic Acid; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ameliorating effects of conventional therapy on declining renal function in patients with diabetic n...
Next Document: Prevalence of tuberculosis in Indonesia, Singapore, Brunei Darussalam and the Philippines.