| Biochemical and histopathological findings of N-butyl-2-cyanoacrylate in oral surgery: an experimental study. | |
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MedLine Citation:
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PMID: 17138158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The increasing use of cyanoacrylates in dentistry, particularly as an adhesive and sealing glue, has raised concerns regarding its potential toxicity in humans. Several different forms of these compounds including methyl- (MCA), ethyl- (ECA), isobutyl-, isohexyl-, and octyl CA have been developed to eliminate tissue toxicity. N-butyl-2-cyanoacrylate is becoming an increasingly popular method for wound closure under low tension. Despite their increasing use, pharmacologic effects of these substances on liver and kidney functions are not widely known. The objective of the present study was to investigate possible immediate and long-term systemic effects of N-butyl-2-cyanoacrylate in oral surgery. STUDY DESIGN: Ten male Wistar rats weighing 220 to 270 g were used in the study. Straight incisions were made to the buccal mucosa of the animals. N-butyl-2-cyanoacrylate adhesive (Indermil) was applied and wounds were closed primarily. Blood specimens were taken periodically from the vena cava of the animals before the surgical procedure and 2, 14, 21, and 65 days after the surgical procedure. The blood specimens of those taken before the application of the adhesive were defined as the control group; blood specimens that were taken 2, 14, 21, and 65 days from the application were defined as study group. The stored plasma samples were analyzed for blood urea nitrogen (BUN), creatinine (CRE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBI), total protein (TP), albumin (ALB), and amylase (AML). In addition to biochemical parameters, histopathological examination was performed. Blood parameter values of the control and study groups were statistically compared with the Duncan test (P < .05). RESULTS: There were no significant differences in the values of BUN, CRE, ALT, AST, TBI, TP, ALB, and AML between the control and at 2, 14, 21, and 65 days. CONCLUSION: The present study shows that N-butyl-2-cyanoacrylate is a suitable adhesive applicable in oral surgery. |
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Authors:
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Samet Inal; Nergiz Yilmaz; Cevat Nisbet; Tolga Güvenç |
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Publication Detail:
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Type: Journal Article Date: 2006-09-25 |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 102 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-01 Completed Date: 2006-12-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: e14-7 Citation Subset: D; IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey. dtsamet@hotmail.com.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Amylases / blood Animals Aspartate Aminotransferases / blood Bilirubin / blood Blood Urea Nitrogen Bone Cements / pharmacokinetics, toxicity* Creatinine / blood Enbucrilate / analogs & derivatives*, pharmacokinetics, toxicity Kidney / drug effects*, metabolism Kidney Function Tests Liver / drug effects*, metabolism Liver Function Tests Male Mouth Mucosa / surgery Oral Surgical Procedures Rats Rats, Wistar Tissue Adhesives / pharmacokinetics, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Bone Cements; 0/Tissue Adhesives; 60-27-5/Creatinine; 635-65-4/Bilirubin; 6606-65-1/Enbucrilate; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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