Document Detail

Biochemical and histological effects of intermittent carbon monoxide exposure in cynomolgus monkeys (Macaca fascicularis) in relation to atherosclerosis.
MedLine Citation:
PMID:  7430413     Owner:  NLM     Status:  MEDLINE    
The data in this report do not suggest any association between periodic carbon monoxide exposure and the development of atherosclerosis in cynomolgus monkeys. Animals were exposed to 200 to 400 ppm CO in the inspired air for 10 alternate half hours daily for approximately 12 months. These conclusions are reached from both histological and biochemical studies (aortic cholesterol content, arterial cholesterol influx, aortic oxygen consumption, as well as plasma triglyceride concentrations and HDL cholesterol to total cholesterol ratios). A rise in plasma and tissue free fatty acids (FFA) was observed in the experimental group exposed to carbon monoxide. However, the increase in FFA tissue levels was not believed to be due to any inhibitory effect of CO on the electron transfer system since mitochondrial respiratory function was not depressed.
R J Bing; J S Sarma; R Weishaar; A Rackl; G Pawlik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  20     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1980 Aug-Sep
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-99     Citation Subset:  IM    
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MeSH Terms
Arteries / pathology
Arteriosclerosis / chemically induced*
Carbon Monoxide / toxicity*
Cholesterol / blood
Electron Transport / drug effects
Fatty Acids, Nonesterified / blood
Lipids / blood
Macaca fascicularis
Mitochondria / drug effects
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lipids; 57-88-5/Cholesterol; 630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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