Document Detail


Biochemical, histological, and biomechanical analyses of canine tendon.
MedLine Citation:
PMID:  3819911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To define the matrix composition and architecture of canine flexor tendon, and to correlate tissue structure with applied mechanical loading, five anatomical regions of flexor tendon were studied. Histologically, two prominent fibrocartilaginous areas were observed on concave aspects of the tendon. The location of the major fibrocartilaginous area at the metacarpophalangeal joint correlated well with the region predicted by biomechanical modeling to be under greatest compressive loads during standing and claw movement. Comparative biochemical analysis showed an elevated water content, a five-fold higher hexuronic acid content, and a larger hydroxylysine/hydroxyproline ratio in this region relative to that for more tendinous areas. The major glycosaminoglycan component of fibrocartilaginous areas was chondroitin sulfate, whereas in other areas dermatan sulfate and hyaluronic acid dominated. Cell density and DNA analyses indicated a slightly higher cellularity for fibrocartilaginous areas and the region of vinculum insertion. These data document the existence of discrete areas of specialization within the flexor tendon that appear to be an adaptation to nutritional and mechanical factors.
Authors:
Y Okuda; J P Gorski; K N An; P C Amadio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  5     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1987-03-31     Completed Date:  1987-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-8     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Dogs
Glycosaminoglycans / analysis
Proteoglycans / analysis
Tendons / analysis,  physiology*
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Proteoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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