Document Detail

Biochemical findings in multiple sclerosis. V. Transformation of lymphocytes from patients with multiple sclerosis by human basic protein.
MedLine Citation:
PMID:  72138     Owner:  NLM     Status:  MEDLINE    
Lymphocyte stimulation tests with human basic protein of myelin were performed on patients with multiple sclerosis, with other neurological diseases and on normal subjects. In both MS and OND group, a hypersensitization to basic protein was seen in about one third of the cases. All normal subjects, except one, had negative responses. In the MS group, a positive correlation could be found with some features of the disease: significantly more positive responses were found in independent patients with a short duration of illness and in those with an oligoclonal distribution in the CSF. The authors compare their results with those of the literature. The possible role of BP in pathogeny of MS and OND is discussed.
F Gosseye-Lissoir; P Delmotte; H Carton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  216     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  197-205     Citation Subset:  IM    
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MeSH Terms
Immunity, Cellular
Immunoglobulins / analysis
Lymphocyte Activation*
Multiple Sclerosis / immunology*,  metabolism
Myelin Sheath
Nerve Tissue Proteins / pharmacology*
Reg. No./Substance:
0/Immunoglobulins; 0/Nerve Tissue Proteins

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