Document Detail


Biochemical evaluation of patients with acute pancreatitis.
MedLine Citation:
PMID:  11156345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we determined the clinical accuracy of alpha2-macroglobulin, alpha-amylase, C-reactive protein, lipase, non-esterified fatty acids, pancreatic alpha-amylase and phospholipase A in the diagnosis and prognosis of acute pancreatitis in a group of patients with acute abdominal pain using receiver operator characteristic curve analysis. We investigated 59 patients with acute pancreatitis and 72 patients with extrapancreatic diseases of gastrointestinal origin. On the basis of initial enzyme activities, at cut-offs of 245 U/l for amylase, 656 U/l for lipase, and 182 U/l for pancreatic alpha-amylase, the diagnostic efficiencies were 0.993, 0.980, and 0.975, respectively. Receiver operator characteristic curve analysis showed the same diagnostic accuracies. We evaluated the accuracy of serum alpha2-macroglobulin, C-reactive protein, non-esterified fatty acids and phospholipase A for differentiation between acute necrotizing pancreatitis and acute oedematous pancreatitis. C-reactive protein had the highest prognostic accuracy of the parameters studied (the area under curve = 0.9082) and at a cut-off value of 126 mg/l, sensitivity and specificity were 0.759 and 0.912, respectively. The role of the clinical laboratory in the investigation of patients with acute pancreatitis continues to evolve and biochemical parameters are a good diagnostic and prognostic option.
Authors:
S Ignjatović; N Majkić-Singh; M Mitrović; M Gvozdenović
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  38     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1141-4     Citation Subset:  IM    
Affiliation:
Institute of Medical Biochemistry, Clinical Center of Serbia and Faculty of Pharmacy, Belgrade, Yugoslavia. tana@eunet.yu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Amylases / blood
C-Reactive Protein / metabolism
Evaluation Studies as Topic
Fatty Acids, Nonesterified / blood
Female
Humans
Lipase / blood
Male
Middle Aged
Pancreatitis / blood*
Phospholipases A / blood
ROC Curve
Sensitivity and Specificity
alpha-Macroglobulins / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/alpha-Macroglobulins; 9007-41-4/C-Reactive Protein; EC 3.1.1.-/Phospholipases A; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases

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