| Biochemical effect of chocolate colouring and flavouring like substances on thyroid function and protein biosynthesis. | |
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MedLine Citation:
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PMID: 1717848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthetic chocolate colourant, flavourant and the mixture of both were administered to healthy adult male albino rats to evaluate their effect on the nucleic acids metabolism, i.e. deoxyribonucleic and ribonucleic acids (DNA and RNA), total serum protein, thyroid hormones (T4 and T3) and nuclease enzymes, i.e. cytoplasmic- and mitochondrial deoxyribonuclease and ribonuclease (DNase and RNase) in brain, liver, and kidneys. Also, the activity of the fundamental enzymes of the oxidative pentose phosphate pathway, i.e. cytoplasmic and mitochondrial glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase (G-6-PD and 6-PGD), as well as total lipids and cholesterol contents in the same organs were studied. Ingestion of the studied food additives significantly increased serum protein, RNA and T4 hormone, while, DNA and T3 hormone were insignificantly elevated. In connection with this, the hydrolytic enzymes of nucleic acids (DNase and RNase activities) were stimulated by all studied food additives and in all mentioned organs. The activity of G-6-PD and 6-PGD in both cytoplasmic and mitochondrial fractions of all studied organs were increased. The highest increase was noticed in rats fed on diets supplemented with the mixture of both colourant and flavourant followed by colourant then flavourant, respectively. |
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Authors:
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S S el-Saadany |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Nahrung Volume: 35 ISSN: 0027-769X ISO Abbreviation: Nahrung Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-04 Completed Date: 1991-11-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0142530 Medline TA: Nahrung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 335-43 Citation Subset: IM |
Affiliation:
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Biochemical Department, Faculty of Agriculture, Zagazig University, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / biosynthesis Brain / drug effects, enzymology Cacao DNA / biosynthesis Deoxyribonucleases / biosynthesis Flavoring Agents / toxicity* Food Coloring Agents / toxicity* Glucosephosphate Dehydrogenase / metabolism Kidney / drug effects, enzymology Liver / drug effects, enzymology Male Pentose Phosphate Pathway / drug effects Phosphogluconate Dehydrogenase / metabolism Protein Biosynthesis* RNA / biosynthesis Rats Ribonucleases / biosynthesis Thyroid Gland / drug effects*, physiology Thyroxine / biosynthesis Triiodothyronine / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Flavoring Agents; 0/Food Coloring Agents; 63231-63-0/RNA; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9007-49-2/DNA; EC 1.1.1.43/Phosphogluconate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 3.1.-/Deoxyribonucleases; EC 3.1.-/Ribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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