| Biochemical dynamics and hypocholesterolemic action of Hibiscus sabdariffa (Karkade). | |
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MedLine Citation:
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PMID: 1787844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male albino rats were fed on a mixture of cholesterol and cholic acid for 12 weeks to induce hypercholesterolemia, then Karkade was administered at 5 and 10% for 9 weeks to evaluate its hypocholesterolemic and hypolipemic effect. The experimental parameters include total lipids, cholesterol, triglycerides and phospholipids. Liver and kidney functions were also investigated in normal, hypo- and hypercholesterolemic rats administered Karkade. A remarkable progress (lowering effect) in the level of different lipid fractions was noticed in spite of the continued cholesterol and cholic acid loading during the treatment. However, blood phospholipids were increased after Karkade administration. Hypercholesterolemia has resulted in an effect on the activity of liver and kidney functions. Therefore, the measurement of serum enzyme activity has provided a useful tool for hepatic recovery. Although the administration of Karkade at 5 and 10% induced a significant decrease in the activity of serum GOT and serum GPT, alkaline and acid phosphatase as well as total serum protein, the values nearly returned to the initial levels after 9 weeks of Karkade administration. |
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Authors:
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S S el-Saadany; M Z Sitohy; S M Labib; R A el-Massry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Nahrung Volume: 35 ISSN: 0027-769X ISO Abbreviation: Nahrung Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-23 Completed Date: 1992-03-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0142530 Medline TA: Nahrung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 567-76 Citation Subset: IM |
Affiliation:
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Biochemistry Department, Faculty of Agriculture, Zagazig University, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
/
blood,
metabolism Alanine Transaminase / blood Alkaline Phosphatase / blood, metabolism Animals Anticholesteremic Agents / pharmacology* Aspartate Aminotransferases / blood Brain Chemistry / drug effects Cholesterol, Dietary / pharmacology Creatinine / blood Diet Egypt Kidney / drug effects, metabolism Lipid Metabolism Lipids / blood Liver / drug effects, metabolism Male Plants, Medicinal / chemistry* Rats Spleen / drug effects, metabolism Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 0/Lipids; 60-27-5/Creatinine; 69-93-2/Uric Acid; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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