Document Detail

Biochemical dynamics and hypocholesterolemic action of Hibiscus sabdariffa (Karkade).
MedLine Citation:
PMID:  1787844     Owner:  NLM     Status:  MEDLINE    
Male albino rats were fed on a mixture of cholesterol and cholic acid for 12 weeks to induce hypercholesterolemia, then Karkade was administered at 5 and 10% for 9 weeks to evaluate its hypocholesterolemic and hypolipemic effect. The experimental parameters include total lipids, cholesterol, triglycerides and phospholipids. Liver and kidney functions were also investigated in normal, hypo- and hypercholesterolemic rats administered Karkade. A remarkable progress (lowering effect) in the level of different lipid fractions was noticed in spite of the continued cholesterol and cholic acid loading during the treatment. However, blood phospholipids were increased after Karkade administration. Hypercholesterolemia has resulted in an effect on the activity of liver and kidney functions. Therefore, the measurement of serum enzyme activity has provided a useful tool for hepatic recovery. Although the administration of Karkade at 5 and 10% induced a significant decrease in the activity of serum GOT and serum GPT, alkaline and acid phosphatase as well as total serum protein, the values nearly returned to the initial levels after 9 weeks of Karkade administration.
S S el-Saadany; M Z Sitohy; S M Labib; R A el-Massry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Nahrung     Volume:  35     ISSN:  0027-769X     ISO Abbreviation:  Nahrung     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142530     Medline TA:  Nahrung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  567-76     Citation Subset:  IM    
Biochemistry Department, Faculty of Agriculture, Zagazig University, Egypt.
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MeSH Terms
Acid Phosphatase / blood,  metabolism
Alanine Transaminase / blood
Alkaline Phosphatase / blood,  metabolism
Anticholesteremic Agents / pharmacology*
Aspartate Aminotransferases / blood
Brain Chemistry / drug effects
Cholesterol, Dietary / pharmacology
Creatinine / blood
Kidney / drug effects,  metabolism
Lipid Metabolism
Lipids / blood
Liver / drug effects,  metabolism
Plants, Medicinal / chemistry*
Spleen / drug effects,  metabolism
Uric Acid / blood
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 0/Lipids; 60-27-5/Creatinine; 69-93-2/Uric Acid; EC Aminotransferases; EC Transaminase; EC Phosphatase; EC Phosphatase

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