| Biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid. | |
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MedLine Citation:
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PMID: 7061879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess correlations between the content of the diamines putrescine and cadaverine in vaginal fluid and the clinical manifestations of vaginitis, a rapid procedure for the determination of diamines has been developed. The procedure involves thin-layer chromatography of the dansylated vaginal washings; then the fluorescence of dansyl diamines is compared with that of dansyl alanine. For 520 college women, the result of the test for diamines was positive in 173 (88%) of 197 women with nonspecific vaginitis or vaginitis due to Trichomonas vaginalis and was negative in 291 (90%) of 323 women without nonspecific vaginitis or vaginitis due to T. vaginalis. The diamine content of vaginal fluid specimens after therapy with metronidazole was correlated with the clinical response to treatment. |
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Authors:
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K C Chen; R Amsel; D A Eschenbach; K K Holmes |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 145 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-45 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cadaverine
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analysis Chromatography, Thin Layer Dansyl Compounds / analysis Diamines / analysis* Female Fluorescence Humans Laboratory Techniques and Procedures / methods Metronidazole / therapeutic use Putrescine / analysis Vagina / analysis* Vaginitis / diagnosis*, drug therapy gamma-Aminobutyric Acid / analysis |
| Grant Support | |
ID/Acronym/Agency:
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AI 19121/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dansyl Compounds; 0/Diamines; 110-60-1/Putrescine; 443-48-1/Metronidazole; 462-94-2/Cadaverine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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