Document Detail

Biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid.
MedLine Citation:
PMID:  7061879     Owner:  NLM     Status:  MEDLINE    
To assess correlations between the content of the diamines putrescine and cadaverine in vaginal fluid and the clinical manifestations of vaginitis, a rapid procedure for the determination of diamines has been developed. The procedure involves thin-layer chromatography of the dansylated vaginal washings; then the fluorescence of dansyl diamines is compared with that of dansyl alanine. For 520 college women, the result of the test for diamines was positive in 173 (88%) of 197 women with nonspecific vaginitis or vaginitis due to Trichomonas vaginalis and was negative in 291 (90%) of 323 women without nonspecific vaginitis or vaginitis due to T. vaginalis. The diamine content of vaginal fluid specimens after therapy with metronidazole was correlated with the clinical response to treatment.
K C Chen; R Amsel; D A Eschenbach; K K Holmes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  145     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  AIM; IM    
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MeSH Terms
Cadaverine / analysis
Chromatography, Thin Layer
Dansyl Compounds / analysis
Diamines / analysis*
Laboratory Techniques and Procedures / methods
Metronidazole / therapeutic use
Putrescine / analysis
Vagina / analysis*
Vaginitis / diagnosis*,  drug therapy
gamma-Aminobutyric Acid / analysis
Grant Support
Reg. No./Substance:
0/Dansyl Compounds; 0/Diamines; 110-60-1/Putrescine; 443-48-1/Metronidazole; 462-94-2/Cadaverine; 56-12-2/gamma-Aminobutyric Acid

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