Document Detail


Biochemical diagnosis of vaginitis: determination of diamines in vaginal fluid.
MedLine Citation:
PMID:  7061879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess correlations between the content of the diamines putrescine and cadaverine in vaginal fluid and the clinical manifestations of vaginitis, a rapid procedure for the determination of diamines has been developed. The procedure involves thin-layer chromatography of the dansylated vaginal washings; then the fluorescence of dansyl diamines is compared with that of dansyl alanine. For 520 college women, the result of the test for diamines was positive in 173 (88%) of 197 women with nonspecific vaginitis or vaginitis due to Trichomonas vaginalis and was negative in 291 (90%) of 323 women without nonspecific vaginitis or vaginitis due to T. vaginalis. The diamine content of vaginal fluid specimens after therapy with metronidazole was correlated with the clinical response to treatment.
Authors:
K C Chen; R Amsel; D A Eschenbach; K K Holmes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  145     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Cadaverine / analysis
Chromatography, Thin Layer
Dansyl Compounds / analysis
Diamines / analysis*
Female
Fluorescence
Humans
Laboratory Techniques and Procedures / methods
Metronidazole / therapeutic use
Putrescine / analysis
Vagina / analysis*
Vaginitis / diagnosis*,  drug therapy
gamma-Aminobutyric Acid / analysis
Grant Support
ID/Acronym/Agency:
AI 19121/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Dansyl Compounds; 0/Diamines; 110-60-1/Putrescine; 443-48-1/Metronidazole; 462-94-2/Cadaverine; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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