Document Detail


Biochemical composition of human peripheral arteries examined with near-infrared Raman spectroscopy.
MedLine Citation:
PMID:  9576085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Near-infrared Raman spectroscopy provides an important new means of analyzing the chemical composition of the arterial wall. The objective of this study was to show that Raman spectroscopy can be used to evaluate the lipid and calcium salt contents of human peripheral arteries. The results extend a recently developed Raman-based method for analyzing the chemical composition of coronary arteries.
METHODS AND RESULTS: We studied 167 segments of carotid and femoral artery wall in various pathologic states. The Raman spectra from these samples was accurately modeled. The resulting chemical concentrations were compared with the amounts of cholesterol and calcium mineral determined at histologic evaluation by an experienced cardiovascular pathologist. Strong correlations between spectroscopic measurements and morphologic findings were demonstrated and validated the applicability of the method to peripheral arteries.
CONCLUSIONS: Raman spectroscopy can provide reliable histochemical information about peripheral and coronary arteries. Such information may help identify rupture-prone plaques before the onset of symptoms and allow aggressive and directed intervention. Accurate knowledge of the chemical composition of a lesion may be useful in selecting the most appropriate treatment.
Authors:
J P Salenius; J F Brennan; A Miller; Y Wang; T Aretz; B Sacks; R R Dasari; M S Feld
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  27     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-28     Completed Date:  1998-05-28     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  710-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, MetroWest Medical Center, Framingham, MA 01701, USA.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / metabolism,  pathology,  therapy
Calcinosis / metabolism,  pathology
Calcium / analysis
Carotid Arteries / chemistry*,  pathology
Carotid Artery Diseases / metabolism,  pathology,  therapy
Cholesterol / analysis
Coloring Agents / diagnostic use
Coronary Disease / metabolism,  pathology
Coronary Vessels / chemistry,  pathology
Durapatite / analysis
Eosine Yellowish-(YS) / diagnostic use
Fatty Acids / analysis
Femoral Artery / chemistry*,  pathology
Fluorescent Dyes / diagnostic use
Foam Cells / pathology
Hematoxylin / diagnostic use
Histocytochemistry
Humans
Peripheral Vascular Diseases / metabolism,  pathology,  therapy
ROC Curve
Reproducibility of Results
Rupture, Spontaneous
Sensitivity and Specificity
Single-Blind Method
Spectroscopy, Near-Infrared* / instrumentation,  methods
Spectrum Analysis, Raman* / instrumentation,  methods
Grant Support
ID/Acronym/Agency:
P41-RR02594/RR/NCRR NIH HHS; R01-HL51265/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Fatty Acids; 0/Fluorescent Dyes; 1306-06-5/Durapatite; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin; 57-88-5/Cholesterol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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