| Biochemical and clinical studies on epileptic patients during two phase I trials with the novel anticonvulsant taltrimide. | |
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MedLine Citation:
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PMID: 3143554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taltrimide (2-phthalimidoethanesulphon-N-isopropylamide), a lipophilic derivative of taurine and a potent anticonvulsant in animal studies, was administered in daily doses of 1 and 2 g for 2 weeks with an interval of 2.5 months in 2 phase I clinical trials to 9 drug-resistant epileptic patients. Seizures and EEG were recorded, and routine laboratory studies conducted. Concentrations of antiepileptic drugs in plasma, of amino acids in urine and plasma, and contents of amino acids, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and cyclic nucleotides in the cerebrospinal fluid were determined. Although no clinical or neurophysiological effects were observed, an increase in the cerebrospinal fluid contents of HVA and cyclic nucleotides and changes in the concentrations of antiepileptic drugs and amino acids were found. The concentrations of HVA correlated with those of 5-HIAA and also with those of the main active metabolite of taltrimide. Biochemical changes due to taltrimide treatment resembled only partly those found after taurine treatment. |
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Authors:
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E M Airaksinen; K Koivisto; T Keränen; A Pitkänen; P J Riekkinen; S S Oja; K M Marnela; J V Partanen; O Tokola; G Gothóni |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Epilepsy research Volume: 1 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1989-01-25 Completed Date: 1989-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / metabolism Anticonvulsants / therapeutic use* Clinical Trials as Topic Epilepsies, Myoclonic / drug therapy*, metabolism Epilepsies, Partial / drug therapy*, metabolism Female Homovanillic Acid / cerebrospinal fluid Humans Male Phthalimides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anticonvulsants; 0/Phthalimides; 306-08-1/Homovanillic Acid; 81428-04-8/taltrimide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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