Document Detail

Biochemical and clinical studies on epileptic patients during two phase I trials with the novel anticonvulsant taltrimide.
MedLine Citation:
PMID:  3143554     Owner:  NLM     Status:  MEDLINE    
Taltrimide (2-phthalimidoethanesulphon-N-isopropylamide), a lipophilic derivative of taurine and a potent anticonvulsant in animal studies, was administered in daily doses of 1 and 2 g for 2 weeks with an interval of 2.5 months in 2 phase I clinical trials to 9 drug-resistant epileptic patients. Seizures and EEG were recorded, and routine laboratory studies conducted. Concentrations of antiepileptic drugs in plasma, of amino acids in urine and plasma, and contents of amino acids, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and cyclic nucleotides in the cerebrospinal fluid were determined. Although no clinical or neurophysiological effects were observed, an increase in the cerebrospinal fluid contents of HVA and cyclic nucleotides and changes in the concentrations of antiepileptic drugs and amino acids were found. The concentrations of HVA correlated with those of 5-HIAA and also with those of the main active metabolite of taltrimide. Biochemical changes due to taltrimide treatment resembled only partly those found after taurine treatment.
E M Airaksinen; K Koivisto; T Keränen; A Pitkänen; P J Riekkinen; S S Oja; K M Marnela; J V Partanen; O Tokola; G Gothóni
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Epilepsy research     Volume:  1     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1989-01-25     Completed Date:  1989-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  308-11     Citation Subset:  IM    
Department of Pediatrics, University of Kuopio, Finland.
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MeSH Terms
Amino Acids / metabolism
Anticonvulsants / therapeutic use*
Clinical Trials as Topic
Epilepsies, Myoclonic / drug therapy*,  metabolism
Epilepsies, Partial / drug therapy*,  metabolism
Homovanillic Acid / cerebrospinal fluid
Phthalimides / therapeutic use*
Reg. No./Substance:
0/Amino Acids; 0/Anticonvulsants; 0/Phthalimides; 306-08-1/Homovanillic Acid; 81428-04-8/taltrimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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