Document Detail

Biochemical and clinical effects of the prophylactic treatment of renal calcium stones with magnesium hydroxide.
MedLine Citation:
PMID:  7441826     Owner:  NLM     Status:  MEDLINE    
Prophylactic treatment with magnesium hydroxide ws instituted in 56 consecutive cases with renal calcium stones. The patients had been investigated previously with regard to the magnesium metabolism. The urinary magnesium excretion increased promptly and remained on a higher level during treatment. No changes were observed in the serum or urinary calcium concentrations. Most patients have undergone treatment for at least 2 years and 45 have been free of recurrences of formations of new stones. The mean stone episode rate during treatment was 0.03 stones per year compared to 0.8 stones per year before treatment was instituted. The natural history of stone disease also was followed in 34 patients with stones who had received no prophylactic therapy and 15 have experienced recurrences after 2 years. Therefore, in comparison, treatment with magnesium hydroxide appeared to reduce the recurrence rate. Apart from minor gastrointestinal discomfort no adverse effects were observed during treatment.
G Johansson; U Backman; B G Danielson; B Fellström; S Ljunghall; B Wikström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  124     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  AIM; IM    
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MeSH Terms
Calcium / metabolism
Kidney Calculi / drug therapy*,  metabolism
Magnesium / therapeutic use*
Magnesium Hydroxide / therapeutic use*
Middle Aged
Reg. No./Substance:
1309-42-8/Magnesium Hydroxide; 7439-95-4/Magnesium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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