| Biochemical characterization of a novel ArsA ATPase complex from Alkaliphilus metalliredigens QYMF. | |
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MedLine Citation:
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PMID: 20553716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The two putative ars operons in Alkaliphilus metalliredigens QYMF are distinctive in that the arsA gene is split in halves, amarsA1 and amarsA2, and, acr3 but not an arsB gene coexists with arsA. Heterologous expression of one of the A. metalliredigensars operons (ars1) conferred arsenite but not antimonite resistance to DeltaarsEscherichia coli. Only the co-expressed AmArsA1 and AmArsA2 displayed arsenite or antimonite stimulated ATPase activity. The results show that AmArsA1-AmArsA2 interaction is needed to form the functional ArsA ATPase. This novel AmArsA1-AmArsA2 complex may provide insight in how it participates with Acr3 in arsenite detoxification. |
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Authors:
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Hsueh-Liang Fu; Barry P Rosen; Hiranmoy Bhattacharjee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-27 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-27 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3089-94 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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chemistry,
genetics*,
metabolism* Antimony Arsenites Gram-Positive Bacteria / genetics, metabolism Operon |
| Grant Support | |
ID/Acronym/Agency:
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GM55425/GM/NIGMS NIH HHS; R37 GM055425/GM/NIGMS NIH HHS; R37 GM055425-27/GM/NIGMS NIH HHS; R37 GM055425-29/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arsenites; 15502-74-6/arsenite; 39349-74-1/antimonite; 7440-36-0/Antimony; EC 3.6.1.-/Adenosine Triphosphatases |
| Comments/Corrections | |
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