Document Detail


Biochemical characterization of exercise-trained porcine myocardium.
MedLine Citation:
PMID:  1833367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine whether cardiac biochemical adaptations are induced by chronic exercise training (ET) of miniature swine. Female Yucatan miniature swine were trained on a treadmill or were cage confined (C) for 16-22 wk. After training, the ET pigs had increased exercise tolerance, lower heart rates during exercise at submaximal intensities, moderate cardiac hypertrophy, increased coronary blood flow capacity, and increased oxidative capacity of skeletal muscle. Myosin from both the C and ET hearts was 100% of the V3 isozyme, and there were no differences between the myosin adenosine triphosphatase (ATPase) or myofibrillar ATPase activities of C and ET hearts. Also, the sarcoplasmic reticulum Ca(2+)-ATPase activity and Na(+)-Ca2+ exchange activity of sarcolemmal vesicles were the same in cardiac muscle of C and ET hearts. Finally, the glycolytic and oxidative capacity of ET cardiac muscle was not different from control, since phosphofructokinase, citrate synthase, and 3-hydroxyacyl-CoA dehydrogenase activities were the same in cardiac tissue from ET and C pigs. We conclude that endurance exercise training does not provide sufficient stress on the heart of a large mammal to induce changes in any of the three major cardiac biochemical systems of the porcine myocardium: the contractile system, the Ca2+ regulatory systems, or the metabolic system.
Authors:
M H Laughlin; C C Hale; L Novela; D Gute; N Hamilton; C D Ianuzzo
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-13     Completed Date:  1991-11-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Affiliation:
Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Azides / pharmacology
Calcium / metabolism
Calcium-Transporting ATPases / antagonists & inhibitors
Cardiac Output / physiology
Cardiomegaly / physiopathology
Citrate (si)-Synthase / metabolism
Coronary Circulation / physiology
Female
Myocardium / metabolism*
Myofibrils / enzymology
Myosins / metabolism
Oxygen Consumption / physiology
Phosphofructokinase-1 / metabolism
Physical Conditioning, Animal*
Sarcoplasmic Reticulum / enzymology
Sodium / metabolism
Swine
Swine, Miniature
Grant Support
ID/Acronym/Agency:
HL-01774/HL/NHLBI NIH HHS; HL-36531/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Azides; 7440-23-5/Sodium; 7440-70-2/Calcium; EC 2.3.3.1/Citrate (si)-Synthase; EC 2.7.1.11/Phosphofructokinase-1; EC 3.6.3.8/Calcium-Transporting ATPases; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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