Document Detail

Biochemical characterization of exercise-trained porcine myocardium.
MedLine Citation:
PMID:  1833367     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether cardiac biochemical adaptations are induced by chronic exercise training (ET) of miniature swine. Female Yucatan miniature swine were trained on a treadmill or were cage confined (C) for 16-22 wk. After training, the ET pigs had increased exercise tolerance, lower heart rates during exercise at submaximal intensities, moderate cardiac hypertrophy, increased coronary blood flow capacity, and increased oxidative capacity of skeletal muscle. Myosin from both the C and ET hearts was 100% of the V3 isozyme, and there were no differences between the myosin adenosine triphosphatase (ATPase) or myofibrillar ATPase activities of C and ET hearts. Also, the sarcoplasmic reticulum Ca(2+)-ATPase activity and Na(+)-Ca2+ exchange activity of sarcolemmal vesicles were the same in cardiac muscle of C and ET hearts. Finally, the glycolytic and oxidative capacity of ET cardiac muscle was not different from control, since phosphofructokinase, citrate synthase, and 3-hydroxyacyl-CoA dehydrogenase activities were the same in cardiac tissue from ET and C pigs. We conclude that endurance exercise training does not provide sufficient stress on the heart of a large mammal to induce changes in any of the three major cardiac biochemical systems of the porcine myocardium: the contractile system, the Ca2+ regulatory systems, or the metabolic system.
M H Laughlin; C C Hale; L Novela; D Gute; N Hamilton; C D Ianuzzo
Related Documents :
3336127 - The use of preoperative exercise testing to predict cardiac complications after arteria...
20848127 - Cardiac output but not stroke volume is similar in a wingate and vo2peak test in young ...
8052767 - Exercise-induced cardiac hypertrophy. fact or fallacy?
14990637 - Enalapril to prevent cardiac function decline in long-term survivors of pediatric cance...
12372007 - In-vitro study of the effect of adrenaline on the functional capacity of human neutroph...
22190027 - Mild dehydration affects mood in healthy young women.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-13     Completed Date:  1991-11-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / physiology
Azides / pharmacology
Calcium / metabolism
Calcium-Transporting ATPases / antagonists & inhibitors
Cardiac Output / physiology
Cardiomegaly / physiopathology
Citrate (si)-Synthase / metabolism
Coronary Circulation / physiology
Myocardium / metabolism*
Myofibrils / enzymology
Myosins / metabolism
Oxygen Consumption / physiology
Phosphofructokinase-1 / metabolism
Physical Conditioning, Animal*
Sarcoplasmic Reticulum / enzymology
Sodium / metabolism
Swine, Miniature
Grant Support
Reg. No./Substance:
0/Azides; 7440-23-5/Sodium; 7440-70-2/Calcium; EC (si)-Synthase; EC; EC ATPases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hydramycin, a new antitumor antibiotic. Taxonomy, isolation, physico-chemical properties, structure ...
Next Document:  Analysis of responses to endothelins 1, 2, and 3 and sarafotoxin 6b in airways of the cat.