Document Detail


Biochemical characteristics and risk factors in non-alcoholic fatty liver.
MedLine Citation:
PMID:  20036859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1 per cent. Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. Subjects with NAFLD were obese, hypertensive and often had signs of disturbances in lipid and glucose metabolism and abnormalities in hepatic functions. These findings show risk factors in the development and offer opportunities for prevention of NAFLD.
Authors:
Ying Wang; Jin Dong; Hong-ying Liu; De-qing Wang; Ya-ping Tian
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Publication Detail:
Type:  Journal Article     Date:  2010-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  2     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Chinese PLA General Hospital, No 28, Fuxing Road, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Analysis of Variance
Aspartate Aminotransferases / blood
China / epidemiology
Cohort Studies
Diabetes Mellitus, Type 2 / complications
Dyslipidemias / complications
Fatty Liver / epidemiology*,  etiology*,  metabolism*,  ultrasonography
Female
Glucose / metabolism
Humans
Hypertension / complications
Lipid Metabolism
Liver / metabolism*,  pathology
Logistic Models
Male
Obesity / complications
Prevalence
Risk Factors
Sex Factors
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
50-99-7/Glucose; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

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