Document Detail


Biochemical changes resulting from the intraperitoneal administration of mercuric chloride and methylmercuric chloride to mice.
MedLine Citation:
PMID:  6158769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
I.p. administration of mercuric chloride (HgCl2) and methylmercuric chloride (MeHgCl) at 1 mg/kg body wt./day for 10 consecutive days markedly influenced the phospholipid, DNA, RNA and protein of various tissues of mice. HgCl2 led to a significant increase (42%) in the liver phospholipid content but to a similar decrease in kidney phospholipid. MeHgCl reduced the phospholipid content of the brain and kidney. Kidney DNA decreased following administration of both HgCl2 and MeHgCl. MeHgCl resulted in the depleted rates of 32P uptake in the DNA fraction of all tissues studied. Both compounds increased liver and testis RNA and reduced the protein content and the 32P uptake from the protein fraction in all tissues studied.
Authors:
M Mehra; K C Kanwar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  6     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA / metabolism
Injections, Intraperitoneal
Male
Mercury / administration & dosage,  toxicity*
Methylmercury Compounds / administration & dosage,  toxicity*
Mice
Phospholipids / metabolism
Proteins / metabolism
RNA / metabolism
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 0/Phospholipids; 0/Proteins; 63231-63-0/RNA; 7439-97-6/Mercury; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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