Document Detail

Biochemical changes in layer and broiler chickens when fed on a high-glucosinolate rapeseed meal.
MedLine Citation:
PMID:  6193844     Owner:  NLM     Status:  MEDLINE    
Diets containing 500 g high-glucosinolate rapeseed meal/kg or an equivalent amount of soybean meal as the only protein supplement were fed to layer-type chickens and two broiler strains from 1 to 56 d of age. Additional groups of the former were maintained on the diets until they were 16 and 28 d old. The rapeseed meal produced thyroid hypertrophy in all strains but reduced the growth rate of only one of the broiler strains. The livers of chickens fed on rapeseed meal were enlarged and DNA analysis indicated hyperplasia, but no macroscopic lesions were found. The activities of aspartate transaminase, lactate dehydrogenase and alkaline phosphatase in the plasma were increased by rapeseed meal, suggesting liver damage. In all strains, feeding rapeseed meal increased plasma total protein, albumin and cholesterol and decreased urate. Hyperglycaemia accompanied by a decrease in plasma triglycerides occurred in the layer strain. Through its extra-thyroidal toxicity (-)5-vinyl-oxazolidine-2-thione (goitrin) was probably responsible for most of these changes.
A W Pearson; N M Greenwood; E J Butler; G R Fenwick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British poultry science     Volume:  24     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  417-27     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Antithyroid Agents / poisoning*
Aspartate Aminotransferases / blood
Chickens / metabolism*
L-Lactate Dehydrogenase / blood
Liver / metabolism
Oxazoles / poisoning*
Plant Poisoning / veterinary*
Poultry Diseases / etiology,  metabolism*
Reg. No./Substance:
0/Antithyroid Agents; 0/Oxazoles; 0/Oxazolidinones; 13190-34-6/goitrin; EC Dehydrogenase; EC Aminotransferases; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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