Document Detail

Biochemical changes after surgical stress in rabbits.
MedLine Citation:
PMID:  7069949     Owner:  NLM     Status:  MEDLINE    
Biochemical changes in blood, i.e. glucose, ketone bodies, lactate, protein, blood urea nitrogen (BUN), and free alanine before and after surgical stress were measured in normal and diabetic rabbits. Both the normal and diabetic rabbits were divided into two groups; the acute phase (0 to 180 minutes after surgery) and the subacute phase (1 to 3 postoperative days). Surgical stress was induced by performing laparotomy under anesthesia. Glucose, ketones, lactate, BUN, and alanine were higher in diabetic than normal animals. Protein level was lower in the diabetics. In the acute phase, normal and diabetic animals showed a similar reaction. In the subacute phase, ketone bodies and BUN increased predominantly in normal animals with no change of glucose levels. In two of the diabetics, an increase in glucose, lactate and alanine was seen. These phenomena support Bessman's postulation of stress which has two of phases, the catecholamine phase and the pituitary-adrenal phase. It is considered that this reaction to surgical stress in the acute phase is due to glycogenolysis i.e., glucose from glycogen and lipolysis i.e., ketones from fat induced by catecholamine, and that increased ketone bodies and glucose levels in the subacute phase are due to ketogenesis i.e., ketones from protein and gluconeogenesis i.e., glucose from protein. In both phases ketonemia is predominant in normal rabbits after surgical stress, suggesting that insulin does not reduce directly lipolysis in the acute phase and ketogenesis in the subacute phase, under conditions of stress.
H Kojima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of surgery     Volume:  12     ISSN:  0047-1909     ISO Abbreviation:  Jpn J Surg     Publication Date:  1982  
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1302176     Medline TA:  Jpn J Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  52-60     Citation Subset:  IM    
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MeSH Terms
Alanine / blood
Blood Glucose / analysis
Blood Proteins / analysis
Blood Urea Nitrogen
Diabetes Mellitus, Experimental / blood,  surgery*
Ketones / blood
Lactates / blood
Lactic Acid
Postoperative Period
Stress, Physiological / blood*
Reg. No./Substance:
0/Blood Glucose; 0/Blood Proteins; 0/Ketones; 0/Lactates; 50-21-5/Lactic Acid; 56-41-7/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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