| Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. | |
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MedLine Citation:
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PMID: 22087357 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To study the combinative effects of nanocerium and selenium in a murine model of diabetes.METHODS: Cerium oxide (CeO(2)) nanoparticles (60 mg/kg per day) and sodium selenite (5 μmol/kg per day) alone or in combination, or the metal form of CeO(2) (60 mg/kg) were administered for 2 wk by intraperitoneal injection to streptozotocin-induced diabetic rats. At the end of treatment blood was collected, liver tissue dissected and then oxidative stress markers, extent of energy depletion and lipid profile were evaluated.RESULTS: Antioxidant enzymes and high density lipoprotein decreased whereas oxidative stress, adenosine diphosphate/adenosine triphospahte levels, cholesterol, triglyceride and low density lipoprotein increased on induction of diabetes. All were improved by a combination of nanocerium and sodium selenite. There was a relative amelioration by CeO(2) nanoparticles or sodium selenite alone, but the metal form of CeO(2) showed no significant improvement.CONCLUSION: The combination of nanocerium and sodium selenite is more effective than either alone in improving diabetes-induced oxidative stress. |
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Authors:
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Nazila Pourkhalili; Asieh Hosseini; Amir Nili-Ahmadabadi; Shokoufeh Hassani; Mohsen Pakzad; Maryam Baeeri; Azadeh Mohammadirad; Mohammad Abdollahi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: World journal of diabetes Volume: 2 ISSN: 1948-9358 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101547524 Medline TA: World J Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: 204-210 Citation Subset: - |
Affiliation:
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Nazila Pourkhalili, Amir Nili-Ahmadabadi, Shokoufeh Hassani, Mohsen Pakzad, Maryam Baeeri, Azadeh Mohammadirad, Mohammad Abdollahi, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical sciences, Tehran 1417614411, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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