Document Detail

Biochemical and biophysical predictors of the response to the induction of labor in nulliparous postterm pregnancy.
MedLine Citation:
PMID:  20932507     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to evaluate the clinical, sonographic, and hormonal variables that influence the success of labor induction in nulliparous postterm pregnancies.
STUDY DESIGN: Fifty nulliparous women with a single postterm pregnancy receiving a slow-release prostaglandin estradiol pessary were prospectively enrolled, and clinical characteristics were analyzed in relation to success of induction of labor. Clinical, sonographic, and hormonal variables were analyzed by univariate statistical analysis and multivariate logistic regression for the prediction of successful induction.
RESULTS: The group of patients delivering within 24 hours differed significantly from the remaining patients by higher Bishop scores, body mass indices, estradiol serum concentrations, estriol to estradiol ratios, and shorter cervices. The combination of cervical length and estriol to estradiol ratio achieved a sensitivity of 100% (95% confidence interval, 71.3-100%) and a specificity of 94.1% (95% confidence interval, 80.3-99.1%).
CONCLUSION: Cervical length and the estriol to estradiol ratio represent good predictive indicators of the response to the induction of labor in postterm pregnancies.
Michela Torricelli; Romina Novembri; Chiara Voltolini; Nathalie Conti; Giulia Biliotti; Enrico Piccolini; Gabriele Cevenini; Roger Smith; Felice Petraglia
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Publication Detail:
Type:  Journal Article     Date:  2010-10-08
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-28     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011. Published by Mosby, Inc.
Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Italy.
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MeSH Terms
Biological Markers / blood
Body Mass Index
Cervical Length Measurement
Estradiol / blood
Estriol / blood
Labor, Induced*
Parity / physiology*
Pregnancy, Prolonged / blood*,  ultrasonography*
Prospective Studies
Regression Analysis
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 50-27-1/Estriol; 50-28-2/Estradiol

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