Document Detail

Biochemical and biological studies on the lipopolysaccharide of Bacteroides nodosus.
MedLine Citation:
PMID:  605298     Owner:  NLM     Status:  MEDLINE    
Lipopolysaccharides (LPS) were extracted from three Bacteroides nodosus isolates by the aqueous phenol method and purified by ultracentrifugation. The structure of B nodosus LPS appears to be similar to enterobacterial LPS, with the polysaccharide component joined to the lipid A moiety through an acid-labile 2-keto-3-deoxyoctonic acid (KDO) linkage. B nodosus LPS contained glucose, galactose, hexosamine, KDO and heptose and no sugars apart from ribose, which was possibly a nucleic acid contaminant, were unique to any of the isolates. Electron microscopic examination indicated a similar morphology to LPS derived from other Gram-negative bacteria. B nodosus LPS was found to exhibit biological properties characteristic of endotoxins, such as pyrogenicity, leucopenic and leucocytotic activity, production of the primary inflammatory response in rabbit skin and Shwartzman reactivity. However, the toxicity of B nodosus LPS was low.
D J Stewart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  23     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-25     Citation Subset:  IM    
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MeSH Terms
Bacteroides / analysis*
Chromatography, Gel
Fever / chemically induced
Galactose / analysis
Glucose / analysis
Leukopenia / chemically induced
Lipopolysaccharides / isolation & purification*,  toxicity
Microscopy, Electron
Phospholipids / analysis
Shwartzman Phenomenon / chemically induced
Reg. No./Substance:
0/Lipopolysaccharides; 0/Phospholipids; 26566-61-0/Galactose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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