| Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G. | |
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MedLine Citation:
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PMID: 19684020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation-induced cytidine deaminase (AID) and APOBEC3G catalyze deamination of cytosine to uracil on single-stranded DNA, thereby setting in motion a regulated hypermutagenic process essential for human well-being. However, if regulation fails, havoc ensues. AID plays a central role in the synthesis of high affinity antibodies, and APOBEC3G inactivates human immunodeficiency virus-1. This minireview highlights biochemical and structural properties of AID and APOBEC3G, showing how studies using the purified enzymes provide valuable insight into the considerably more complex biology governing antibody generation and human immunodeficiency virus inactivation. |
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Authors:
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Linda Chelico; Phuong Pham; John Petruska; Myron F Goodman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-08-13 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 284 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-11-10 Revised Date: 2010-10-12 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 27761-5 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California 90089-2910, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Pair Mismatch Cytidine Deaminase / chemistry*, genetics, immunology* Cytosine / chemistry, metabolism* DNA, Single-Stranded / genetics, metabolism HIV-1 / immunology Humans Immunoglobulins / chemistry, genetics, immunology Models, Molecular Protein Structure, Quaternary Protein Structure, Tertiary Protein Subunits / chemistry, genetics, metabolism Retroviridae* / genetics, metabolism Somatic Hypermutation, Immunoglobulin / genetics, immunology Uracil / chemistry, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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ES013192/ES/NIEHS NIH HHS; R37GM21422/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Single-Stranded; 0/Immunoglobulins; 0/Protein Subunits; 66-22-8/Uracil; 71-30-7/Cytosine; EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.5/APOBEC3G protein, human; EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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