Document Detail

Biochemical assessment of the nutritional status of cystic fibrosis patients treated with pancreatic enzyme extracts.
MedLine Citation:
PMID:  9583849     Owner:  NLM     Status:  MEDLINE    
We examined the protein and fat nutritional status of 65 cystic fibrosis patients aged 4-26 y (x +/- SD: 11.2 +/- 5.6 y). Patients were treated with pancreatic enzyme extracts to improve nutrient absorption; in addition, most patients were supplemented with vitamins A and E. Results were compared with those in a control group of 39 subjects aged 5-29 y (x: 14.3 +/- 5.6 y) with no digestive diseases or nutritional deficiencies. Protein determination showed low albumin concentrations in 42% of the cystic fibrosis patients and decreased blood concentrations of retinol binding protein in 12% of the patients. Lipoprotein components were characterized by decreased cholesterol concentrations in 25% of the cystic fibrosis group. Also, mean concentrations of apolipoprotein A-I were significantly lower in the cystic fibrosis group than in control subjects. The results of fatty acid status, expressed in relative (%) and absolute (mg/L) values, showed concentrations of essential fatty acids, represented by linoleic and arachidonic acids, to be significantly decreased in cystic fibrosis patients; this decrease was markedly significant for fatty acid status expressed in absolute values, especially in the cholesteryl ester subfraction. Serum retinol and alpha-tocopherol concentrations were lowered by 8% and 46% in cystic fibrosis patients and control subjects, respectively: retinol, 1.80 +/- 0.50 and 2.37 +/- 0.60 micromol/L, P < 0.001, and alpha-tocopherol, 18.1 +/- 8.7 and 25.7 +/- 5.0 micromol/L, P < 0.001. In conclusion, despite regular treatment with pancreatic enzyme replacements, neither protein nor fat malnutrition in cystic fibrosis patients was completely corrected.
H Benabdeslam; I Garcia; G Bellon; R Gilly; A Revol
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  67     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  912-8     Citation Subset:  AIM; IM    
Laboratoire de Biochimie B et d'Immunologie, UF Lipides-Glucides, Centre Hospitalier Lyon Sud, France.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Child, Preschool
Cholesterol Esters / blood
Cystic Fibrosis / blood*,  drug therapy*
Fatty Acids / blood
Lipoproteins / blood
Nutritional Status*
Pancreas / enzymology
Pancreatic Extracts / therapeutic use*
Pancreatin / therapeutic use
Phospholipids / blood
Retinol-Binding Proteins / metabolism
Vitamins / blood
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol Esters; 0/Fatty Acids; 0/Lipoproteins; 0/Pancreatic Extracts; 0/Phospholipids; 0/Retinol-Binding Proteins; 0/Vitamins; 8049-47-6/Pancreatin
Comment In:
Am J Clin Nutr. 1998 May;67(5):817-8   [PMID:  9583835 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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