Document Detail

Biochemical aspects of protein synthesis inhibition by cycloheximide in one or both hemispheres of the chick brain.
MedLine Citation:
PMID:  482315     Owner:  NLM     Status:  MEDLINE    
Instracrnial administration of cycloheximide into one hemisphere of the chick brain resulted in inhibition of 14C-leucine incorporation into protein only in that hemisphere when the labelled amino acid was administered intracranially. With pericardial injections of labelled amino acid, inhibition of 14C-leucine incorporation was obtained in both the CXM-treated and the untreated hemisphere, when compared with bilateral saline-treated controls. The levels of inhibition were comparable to those obtained with bilateral administration of CXM. There was, however, a slight but significantly higher level of inhibition in the CXM-treated hemisphere. The results were interpreted as supporting the conclusion that monocular learning in chicks resulted in the formation of an engram only in the trained hemisphere.
M E Gibbs; A L Richdale; K T Ng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  10     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  929-31     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / metabolism
Brain / drug effects,  metabolism*
Cycloheximide / pharmacology*
Leucine / metabolism
Nerve Tissue Proteins / biosynthesis*
Time Factors
Reg. No./Substance:
0/Nerve Tissue Proteins; 61-90-5/Leucine; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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