| Biochemical, anatomical and functional correlates of postnatal development of the capsaicin-sensitive innervation of the rat urinary bladder. | |
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MedLine Citation:
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PMID: 2460197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The postnatal development of substance P-like immunoreactivity (SP-LI) in the urinary bladder (assayed by radioimmunoassay and immunohistochemistry) was investigated in rats and compared with changes in the contractile response to acetylcholine, SP or capsaicin. In adult rats, bladder SP-LI was depleted by systemic capsaicin desensitization or extrinsic bladder denervation indicating that it is completely stored in sensory nerves. Bladder SP-LI was not detected in rat fetuses nor in newborn rats until day 3 of postnatal life (P3). SP-LI increased thereafter to reach, at P20, values approaching 60% of the SP-LI observed in the adult rat. By immunohistochemistry, SP-LI positive varicose fibers were not observed until P13. The contractile response to capsaicin was absent at P0, both in vivo (topical application) and in vitro. In adult rats, the capsaicin-induced bladder contraction was abolished by extrinsic denervation and is produced by release of transmitters from sensory nerves. The amplitude of the capsaicin-induced contraction in the postnatal rat bladder was significantly correlated with SP-LI concentration in the organ. Bladders excised from newborn (P0) or adult rats were equally sensitive to exogenous SP which, in both cases, produced a concentration-related contraction. It is concluded that the postnatal development of the 'efferent' function mediated by capsaicin-sensitive nerves of the rat bladder is strictly related to development of peptidergic sensory innervation. |
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Authors:
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C A Maggi; P Santicioli; P Geppetti; S Frilli; M G Spillantini; C Nediani; S P Hunt; A Meli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 471 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 183-90 Citation Subset: IM |
Affiliation:
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Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals, Florence, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Aging / metabolism* Animals Capsaicin / pharmacology* Female Male Muscle Contraction / drug effects Neurons, Afferent / drug effects, metabolism*, physiology Rats Rats, Inbred Strains Substance P / metabolism*, pharmacology, physiology Urinary Bladder / drug effects, growth & development, innervation* |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P; 404-86-4/Capsaicin; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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