Document Detail


Biochemical analysis of heterotopic ossification in spinal cord injury patients.
MedLine Citation:
PMID:  7478729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heterotopic ossification (HO) represents a frequent complication in spinal cord injury (SCI) patients. Samples of HO taken from SCI patients were studied and compared to normal bone. We used a procedure of bone particle fractionation (according to their degree of mineralisation) which allowed us to establish a profile reflecting the metabolic remodeling of bone and to analyse the organic matrix of the newly synthesised tissue. In paraplegic patients, we noted that there was a large increase of the proportion of a degree of calcified bone in the HO as we had previously observed in cortical as well as in cancellous bone of the same patients. Based on aminoacid analyses, we observed in the newly synthesised organic matrix of HO a decreased proportion of hydroxyprolyl residues resulting either from an alteration of the prolyl hydroxylation or from the presence of an excess of non-collagen polypeptides. These results are similar to those seen in sublesional bone of the SCI patients. This study demonstrates that HO is a newly formed bone which has a high rate of turnover as is seen in growing bone. This must be taken into account for the treatment of the patients.
Authors:
A Chantraine; B Nusgens; C M Lapiere
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paraplegia     Volume:  33     ISSN:  0031-1758     ISO Abbreviation:  Paraplegia     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985038R     Medline TA:  Paraplegia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  398-401     Citation Subset:  IM; S    
Affiliation:
Division de Médecine Physique et de Rééducation, Hôpital Cantonal Universitaire, Beau-Séjour, Genève, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / metabolism
Bone Density / physiology
Bone Matrix / metabolism
Bone Remodeling / physiology
Bone and Bones / metabolism
Collagen / metabolism
Female
Humans
Male
Ossification, Heterotopic / etiology,  metabolism*
Protein Processing, Post-Translational / physiology
Spinal Cord Injuries / complications,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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