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Biochemical acromegaly in patients with prolactinoma during treatment with dopaminergic agonists.
MedLine Citation:
PMID:  20857059     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the frequency of subclinical acromegaly (in the absence of clinical phenotype but biochemically uncontrolled) in patients with prolactinoma during treatment with dopaminergic agonists.
SUBJECTS AND METHODS: One hundred twenty one patients without a phenotype suggestive of acromegaly were studied.
RESULTS: Initially, the laboratory diagnosis of acromegaly was unequivocal (elevated IGF-1 for gender and age with nadir GH > 1 μg/L) in two patients, and likely (elevated IGF-1 with nadir GH > cut-off but < 1 μg/L) in another patient. In two other patients, this diagnosis was possible (normal IGF-1 with nadir GH > 1 μg/L). Repetition of the tests 6 months after withdrawal of the dopaminergic agonist confirmed the diagnosis of subclinical acromegaly (elevated IGF-1 for gender and age with nadir GH > 1 μg/L) in these 5 patients. False-positive results were excluded in all cases.
CONCLUSION: In patients with prolactinomas, acromegaly should be investigated not only in cases with a clinical phenotype.
Authors:
Pedro W Rosário; Saulo Purisch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos brasileiros de endocrinologia e metabologia     Volume:  54     ISSN:  1677-9487     ISO Abbreviation:  Arq Bras Endocrinol Metabol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403437     Medline TA:  Arq Bras Endocrinol Metabol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  546-9     Citation Subset:  IM    
Affiliation:
Laboratório ANALYS, Belo Horizonte, MG, Brazil. pedrorosario@globo.com
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