| Biochemical acromegaly in patients with prolactinoma during treatment with dopaminergic agonists. | |
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MedLine Citation:
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PMID: 20857059 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the frequency of subclinical acromegaly (in the absence of clinical phenotype but biochemically uncontrolled) in patients with prolactinoma during treatment with dopaminergic agonists. SUBJECTS AND METHODS: One hundred twenty one patients without a phenotype suggestive of acromegaly were studied. RESULTS: Initially, the laboratory diagnosis of acromegaly was unequivocal (elevated IGF-1 for gender and age with nadir GH > 1 μg/L) in two patients, and likely (elevated IGF-1 with nadir GH > cut-off but < 1 μg/L) in another patient. In two other patients, this diagnosis was possible (normal IGF-1 with nadir GH > 1 μg/L). Repetition of the tests 6 months after withdrawal of the dopaminergic agonist confirmed the diagnosis of subclinical acromegaly (elevated IGF-1 for gender and age with nadir GH > 1 μg/L) in these 5 patients. False-positive results were excluded in all cases. CONCLUSION: In patients with prolactinomas, acromegaly should be investigated not only in cases with a clinical phenotype. |
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Authors:
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Pedro W Rosário; Saulo Purisch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arquivos brasileiros de endocrinologia e metabologia Volume: 54 ISSN: 1677-9487 ISO Abbreviation: Arq Bras Endocrinol Metabol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403437 Medline TA: Arq Bras Endocrinol Metabol Country: Brazil |
Other Details:
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Languages: eng Pagination: 546-9 Citation Subset: IM |
Affiliation:
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Laboratório ANALYS, Belo Horizonte, MG, Brazil. pedrorosario@globo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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