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Biochemical studies on active transport.
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MedLine Citation:
PMID:  19873625     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The active transport process, so important in cell function, has been studied in the past with intact cells. Models which have arisen from this work all depend on: first, a specific protein to recognize the substrate; second, translocation of the substrate across the cell membrane; third, release of substrate within the cell and restoration of the system to its initial state. These steps are adequate for facilitated transport, but in active transport an energy input is required to maintain a concentration gradient. Parts of transport systems have been isolated recently. A protein which specifically recognizes beta-galactosides has been partially purified. In another case, a protein that appears to be the recognition part of the sulfate transport system of Salmonella typhimurium has been crystallized, and many of its properties have been described. The role of this protein in recognition and in translocation is discussed. Also proteins that phosphorylate a variety of sugars as they enter the cell's interior provide a mechanism for concentrating sugars as their phosphates, against a gradient.
A B Pardee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  52     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1968 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-95     Citation Subset:  -    
Program in Biochemical Sciences, Moffett Laboratory, Princeton University, Princeton, New Jersey 08540.
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Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
Copyright © 1968 by The Rockefeller University Press
Print publication date: Day: 1 Month: 7 Year: 1968
Volume: 52 Issue: 1
First Page: 279 Last Page: 295
ID: 2225799
PubMed Id: 19873625

Biochemical Studies on Active Transport
Arthur B. Pardee
From the Program in Biochemical Sciences, Moffett Laboratory, Princeton University, Princeton, New Jersey 08540

Article Categories:
  • Transport across Cell Membranes
    • Article

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