Document Detail

Biochemical aspirin resistance and recurrent lesions in patients with acute ischemic stroke.
MedLine Citation:
PMID:  20606449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of biochemical aspirin resistance (BAR) on ischemic stroke has not been well established. Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging (DWI) are proposed as potential surrogate markers of clinically recurrent stroke. METHODS: We included 117 consecutive patients who (1) were admitted within 24 h of symptom onset; (2) had an ischemic stroke confirmed by DWI; (3) underwent follow-up DWI within seven days after onset, and (4) received aspirin treatment. BAR was measured using the VerifyNow(R) Aspirin Assay. We analyzed the associations between BAR and any ERILs (overall ERILs), and between BAR and ERILs occurring outside the vascular territories of index stroke (distant ERILs). RESULTS: BAR was observed in 16 (13.7%) patients. Overall ERILs were detected in 34 (29.1%), and distant ERILs in 10 (8.5%) patients. Patients with BAR were more likely to develop ERILs, but the association was not significant (OR 2.13; 95% CI 0.72-6.29; p = 0.234). However, BAR was independently related to distant ERILs by logistic regression analysis (OR 6.01; 95% CI 1.29-28.09; p = 0.023). CONCLUSIONS: BAR was associated with distant ERILs but not with overall ERILs during the first week after ischemic stroke.
Sang-Beom Jeon; Ha-Sup Song; Bum Joon Kim; Hye-Jin Kim; Dong-Wha Kang; Jong S Kim; Sun U Kwon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-03
Journal Detail:
Title:  European neurology     Volume:  64     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Stroke Center and Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*,  adverse effects
Aspirin / administration & dosage*,  adverse effects
Diffusion Magnetic Resonance Imaging / methods
Drug Resistance
Follow-Up Studies
Logistic Models
Middle Aged
Retrospective Studies
Stroke / diagnosis*,  drug therapy*,  physiopathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

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