| Biochemical aspirin resistance and recurrent lesions in patients with acute ischemic stroke. | |
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MedLine Citation:
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PMID: 20606449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effect of biochemical aspirin resistance (BAR) on ischemic stroke has not been well established. Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging (DWI) are proposed as potential surrogate markers of clinically recurrent stroke. METHODS: We included 117 consecutive patients who (1) were admitted within 24 h of symptom onset; (2) had an ischemic stroke confirmed by DWI; (3) underwent follow-up DWI within seven days after onset, and (4) received aspirin treatment. BAR was measured using the VerifyNow(R) Aspirin Assay. We analyzed the associations between BAR and any ERILs (overall ERILs), and between BAR and ERILs occurring outside the vascular territories of index stroke (distant ERILs). RESULTS: BAR was observed in 16 (13.7%) patients. Overall ERILs were detected in 34 (29.1%), and distant ERILs in 10 (8.5%) patients. Patients with BAR were more likely to develop ERILs, but the association was not significant (OR 2.13; 95% CI 0.72-6.29; p = 0.234). However, BAR was independently related to distant ERILs by logistic regression analysis (OR 6.01; 95% CI 1.29-28.09; p = 0.023). CONCLUSIONS: BAR was associated with distant ERILs but not with overall ERILs during the first week after ischemic stroke. |
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Authors:
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Sang-Beom Jeon; Ha-Sup Song; Bum Joon Kim; Hye-Jin Kim; Dong-Wha Kang; Jong S Kim; Sun U Kwon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-03 |
Journal Detail:
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Title: European neurology Volume: 64 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 51-7 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Stroke Center and Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*, adverse effects Aspirin / administration & dosage*, adverse effects Diffusion Magnetic Resonance Imaging / methods Drug Resistance Female Follow-Up Studies Humans Logistic Models Male Middle Aged Recurrence Retrospective Studies Stroke / diagnosis*, drug therapy*, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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