Document Detail


The Biochemical Aspects of a Non-ST-Segment Elevation Acute Coronary Syndrome.
MedLine Citation:
PMID:  23160164     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The clinical course of an acute coronary syndrome can vary from relatively benign to potentially fatal. The biomarkers of myocardial necrosis relate to the amount of myocardial damage and are closely linked to a patient's prognosis. They are measured to help guide management decisions. Recent interest in myocardial neurohumoral mechanisms has identified the natriuretic peptides as strong prognostic biomarkers following an ischemic event. During an acute event they provide information regarding the area of myocardium at risk. The biomarkers of inflammation, such as C-reactive protein, are related to both the development of atherosclerosis and the risk of acute ischemic events. The mechanism characterizing the pathophysiology of the syndrome is represented by these cardiac biomarkers. Assessing combinations of pathobiologically diverse biomarkers may provide a better risk evaluation method and further dictate subsequent therapy.
Authors:
Robert K Riezebos; Freek W A Verheugt; Gerrit J Laarman; Jan G P Tijssen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  13     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e70-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
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