Document Detail

Biocatalytic synthesis of ascorbyl esters and their biotechnological applications.
MedLine Citation:
PMID:  19030854     Owner:  NLM     Status:  MEDLINE    
Ascorbyl fatty acid esters act both as antioxidants and surfactants. These esters are obtained by acylation of vitamin C using different acyl donors in presence of chemical catalysts or lipases. Lipases have been used for this reaction as they show high regioselectivity and can be used under mild reaction conditions. Insolubility of hydrophilic ascorbic acid in non-polar solvents is the major obstacle during ascorbic acid esters synthesis. Different strategies have been invoked to address this problem viz. use of polar organic solvents, ionic liquids, and solid-phase condensation. Furthermore, to improve the yield of ascorbyl fatty acid esters, reactions were performed by (1) controlling water content in the reaction medium, (2) using vacuum to remove formed volatile side product, and (3) employing activated acyl donors (methyl, ethyl or vinyl esters of fatty acids). This mini-review offers a brief overview on lipase-catalyzed syntheses of vitamin C esters and their biotechnological applications. Also, wherever possible, technical viability, scope, and limitations of different methods are discussed.
Sanjib Kumar Karmee
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-11-22
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  81     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1013-22     Citation Subset:  IM    
Institut für Technische und Makromolekulare Chemie, RWTH-Aachen University, 52074 Aachen, Germany.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / analogs & derivatives*
Biotechnology / methods
Fatty Acids / metabolism*
Lipase / metabolism
Surface-Active Agents / metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 0/Surface-Active Agents; 50-81-7/Ascorbic Acid; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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