Document Detail


Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry.
MedLine Citation:
PMID:  19757497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transaminases catalyze amino transfer reactions from amino donors such as amino acids or amines to keto acids or ketones to give chiral amino acid or amines in optically pure form. alpha-Amino acid dehydrogenases catalyze the asymmetric reductive amination of alpha-keto acids using ammonia as amino donor to furnish L-amino acids. The distinct features and synthetic application of these two enzymes are reviewed in an effort to illustrate their promising and challenging aspects in serving as approaches to the direct asymmetric synthesis of optically pure amines from the corresponding keto compounds, a formidable problem in organic chemistry.
Authors:
Dunming Zhu; Ling Hua
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biotechnology journal     Volume:  4     ISSN:  1860-7314     ISO Abbreviation:  Biotechnol J     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265833     Medline TA:  Biotechnol J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1420-31     Citation Subset:  IM    
Affiliation:
State Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. jadezhu@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Amination
Amines / chemistry,  metabolism
Chemistry, Organic / methods*
Models, Chemical
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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