| Biobehavioral effects of extended salt loading and conflict stress in intact baboons. | |
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MedLine Citation:
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PMID: 8169575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Behavioral stressors may inhibit sodium excretion, potentially increasing plasma volume and elevating blood pressure during chronic exposure. Blood pressure regulation may be especially deranged during manipulations that further challenge the kidney, such as a diet high in salt content. The effects on blood pressure and other variables of combined behavioral stress (food/shock conflict) and dietary salt (12 g NaCl per day; 218 mEq Na+ per day) were examined in adult male baboons over the course of 1 year. Mean arterial pressure was not significantly elevated over baseline after 5 months of high dietary salt alone (6 +/- 5 mmHg) but was maximally elevated by an average of 17 (+/- 3 SEM) mmHg after 5 months of combined salt and conflict stress. Control baboons showed no significant trends in mean arterial pressure across the same time period. Individual subjects whose blood pressure was "salt+stress resistant" or "salt+stress sensitive" were differentiated by their degree of pressure diuresis and natriuresis, urinary free cortisol, and a behavioral index of stress sensitivity. The data indicate additive effects of chronic high dietary salt intake and behavioral stressors on blood pressure in nonhuman primates that are dependent on renal function and pituitary-adrenocortical activity. |
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Authors:
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J S Turkkan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the experimental analysis of behavior Volume: 61 ISSN: 0022-5002 ISO Abbreviation: J Exp Anal Behav Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-06-02 Completed Date: 1994-06-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0203727 Medline TA: J Exp Anal Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-72 Citation Subset: IM |
Affiliation:
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Johns Hopkins University School of Medicine, Baltimore, Maryland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology* Blood Pressure / physiology* Diuresis Electrolytes / blood Electroshock Heart Rate Male Natriuresis Papio / physiology* Sodium Chloride / metabolism*, urine Stress, Psychological / metabolism, psychology* |
| Grant Support | |
ID/Acronym/Agency:
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HL40138/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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