Document Detail


Biobehavioral effects of extended salt loading and conflict stress in intact baboons.
MedLine Citation:
PMID:  8169575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioral stressors may inhibit sodium excretion, potentially increasing plasma volume and elevating blood pressure during chronic exposure. Blood pressure regulation may be especially deranged during manipulations that further challenge the kidney, such as a diet high in salt content. The effects on blood pressure and other variables of combined behavioral stress (food/shock conflict) and dietary salt (12 g NaCl per day; 218 mEq Na+ per day) were examined in adult male baboons over the course of 1 year. Mean arterial pressure was not significantly elevated over baseline after 5 months of high dietary salt alone (6 +/- 5 mmHg) but was maximally elevated by an average of 17 (+/- 3 SEM) mmHg after 5 months of combined salt and conflict stress. Control baboons showed no significant trends in mean arterial pressure across the same time period. Individual subjects whose blood pressure was "salt+stress resistant" or "salt+stress sensitive" were differentiated by their degree of pressure diuresis and natriuresis, urinary free cortisol, and a behavioral index of stress sensitivity. The data indicate additive effects of chronic high dietary salt intake and behavioral stressors on blood pressure in nonhuman primates that are dependent on renal function and pituitary-adrenocortical activity.
Authors:
J S Turkkan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  61     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-72     Citation Subset:  IM    
Affiliation:
Johns Hopkins University School of Medicine, Baltimore, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Blood Pressure / physiology*
Diuresis
Electrolytes / blood
Electroshock
Heart Rate
Male
Natriuresis
Papio / physiology*
Sodium Chloride / metabolism*,  urine
Stress, Psychological / metabolism,  psychology*
Grant Support
ID/Acronym/Agency:
HL40138/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Electrolytes; 7647-14-5/Sodium Chloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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